{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:39:32Z","timestamp":1775626772810,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973492"],"award-info":[{"award-number":["81973492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>Xiaoer Huanglong Granule is the only Chinese Patent Medicine widely used for treating attention deficit hyperactivity disorder. However, not much is known about the bioactive components and pharmacokinetics of Xiaoer Huanglong Granule even after it was successfully introduced into clinical use. This study analyzed the components in the medication and rat plasma after oral administration with the help of the UNIFI platform and Masslynx. A total of 119 and 37 components were detected in the medication and plasma, respectively, using an ultra\u2010performance liquid chromatography\u2010tandem mass spectrometer. We established a rapid and sensitive simultaneous determination of one triterpene saponin, three monoterpene glycosides, and three lignans in rat plasma by solid\u2010phase extraction. The determination was accomplished within 7.50\u00a0min via gradient elution. The values of the lower limit of quantitation were validated at 0.08\u00a0ng\/ml for tenuifolin, 0.8\u00a0ng\/ml for lactiflorin, 1.828\u00a0ng\/ml for albiflorin, 2\u00a0ng\/ml for paeoniflorin, gomisin B, and gomisin D, 10\u00a0ng\/ml for schisandrin. The results from validations of other methods were all acceptable (relative standard deviation \u2264 14.94%). This is the first report on the identification and pharmacokinetics studies of components in Xiaoer Huanglong Granule. Moreover, the pharmacokinetic behavior of lactiflorin was studied for the first time.<\/jats:p>","DOI":"10.1002\/jssc.202200245","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T12:50:01Z","timestamp":1654347001000},"page":"2804-2818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phytochemical identification of Xiaoer Huanglong Granule and pharmacokinetic study in the rat using its seven major bioactive components"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-8126","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. 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