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The obtained cross\u2010linked amido\u2010amino network silica material exhibited superior hydrolytic stability compared to classical 3\u2010aminopropyl phases and showed, inter alia, excellent separation of nine therapeutically effective sulfonamides in hydrophilic interaction\/weak anion exchange chromatography elution mode. Additionally, the separation of carbohydrates was investigated under classical hydrophilic interaction chromatography conditions as well proving the suitability of the novel phase for such applications. For the evaluation of the hydrolytic stability the prepared material, as well as two commercially available benchmark columns and a set of in\u2010house synthesized amino\u2010modified materials, were exposed to harsh aqueous mobile phase conditions for in total of 50\u00a0h at elevated temperature. In this context, the materials were examined by elemental analysis, (<jats:sup>13<\/jats:sup>C and <jats:sup>29<\/jats:sup>Si cross\u2010polarization\/magic angle spinning) solid\u2010state nuclear magnetic resonance, and a chromatographic test before and subsequent to the exposure to these stress conditions. Lastly, the new stationary phase was classified in comparison to a set of commercially available stationary phases by principal component analysis of resultant retention factors gained from chromatographic standard tests.<\/jats:p>","DOI":"10.1002\/jssc.202200268","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T08:37:19Z","timestamp":1654159039000},"page":"3286-3300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Development and chromatographic exploration of stable\u2010bonded cross\u2010linked amino silica against classical amino phases"],"prefix":"10.1002","volume":"45","author":[{"given":"Marc","family":"Wolter","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Sciences, Pharmaceutical (Bio\u2010)Analysis University of T\u00fcbingen  T\u00fcbingen 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