{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T01:12:17Z","timestamp":1779153137191,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T00:00:00Z","timestamp":1679184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22176210"],"award-info":[{"award-number":["22176210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876199"],"award-info":[{"award-number":["21876199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>The molecular imprinting technique has aroused great interest in preparing novel stationary phases, and the resulting materials named molecularly imprinted polymers coated silica packing materials exhibit good performance in separating diverse analytes based on their good characteristics (including high selectivity, simple synthesis, and good chemical stability). To date, mono\u2010template is commonly used in synthesizing molecularly imprinted polymers\u2010based stationary phases. The resulting materials always own the disadvantages of low column efficiency and restricted analytes, and the price of ginsenosides with high purity was very high. In this study, to overcome the weaknesses of molecularly imprinted polymers\u2010based stationary phases mentioned above, the multi\u2010templates (total saponins of folium ginseng) strategy was used to prepare ginsenosides imprinted polymer\u2010based stationary phase. The resulting ginsenosides imprinted polymer\u2010coated silica stationary phase has a good spherical shape and suitable pore structures. Additionally, the total saponins of folium ginseng were cheaper than other kinds of ginsenosides. Moreover, the ginsenosides imprinted polymer\u2010coated silica stationary phase\u2010packed column performed well in the separation of ginsenosides, nucleosides, and sulfonamides. The ginsenosides imprinted polymer\u2010coated silica stationary phase possesses good reproducibility, repeatability, and stability for seven days. Therefore, a multi\u2010templates strategy for synthesizing the ginsenosides imprinted polymer\u2010coated silica stationary phase is considered in the future.<\/jats:p>","DOI":"10.1002\/jssc.202200825","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T09:20:07Z","timestamp":1678353607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and evaluation of ginsenosides imprinted polymer\u2010based chromatographic stationary phase"],"prefix":"10.1002","volume":"46","author":[{"given":"Junping","family":"Xue","sequence":"first","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuichi","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Arabi","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Research Center for Coastal Environmental Engineering and Technology Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Research Center for Coastal Environmental Engineering and Technology Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guisheng","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6030-3570","authenticated-orcid":false,"given":"Gangqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3764-3515","authenticated-orcid":false,"given":"Lingxin","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Research Center for Coastal Environmental Engineering and Technology Yantai Institute of Coastal Zone Research Chinese Academy of Sciences  Yantai P. R. China"},{"name":"School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2299-722X","authenticated-orcid":false,"given":"Zhihua","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Ministry of Education Yantai University  Yantai P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2022.107670"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462453"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116318"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202001086"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.04.002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201901341"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123079"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460542"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2016.06.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.12.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200619115444"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2017.01.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2022.106162"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.38212\/2224-6614.3348"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153511"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112875"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112659"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-017-0962-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2014.986562"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114225"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b03408"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25061407"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.12.009"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2014.12.003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-020-02301-z"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.12.026"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2015.12.001"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.339829"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201900765"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2016.02.038"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3724\/SP.J.1123.2021.07008"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.03.026"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462534"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2021.116504"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.462914"},{"key":"e_1_2_9_37_1","article-title":"Recent advances of restricted access molecularly imprinted materials and their applications in food and biological samples analysis. TRAC\u2010Trend","volume":"147","author":"Wang H","year":"2022","journal-title":"Anal Chem"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201801258"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.123115"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.113291"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460659"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2021.128200"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11144-021-02132-3"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.462933"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.09.016"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.10.008"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.339608"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2019.01.005"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2018.10.001"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098887"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2022.194902"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00903"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13979"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202200825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.202200825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202200825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:42:37Z","timestamp":1760881357000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.202200825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,19]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/jssc.202200825"],"URL":"https:\/\/doi.org\/10.1002\/jssc.202200825","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,19]]},"assertion":[{"value":"2022-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2200825"}}