{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:02:01Z","timestamp":1789966921219,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:p>\n                    3\u2010Chloro\u20101,2\u2010propanediol is a common food contaminant, but reports on its determination in biological tissues are lacking. In the present study, a method was developed to detect 3\u2010chloro\u20101,2\u2010propanediol contents in rat tissues by quick\u2010easy\u2010cheap\u2010effective\u2010rugged\u2010and\u2010safe extraction and gas chromatography\u2010mass spectrometry analysis. Biological samples were extracted with ethyl acetate and purified with adsorbents. The optimized adsorbent for each sample was selected from 4\u20135 combinations of\n                    <jats:italic>N<\/jats:italic>\n                    \u2010propylethylenediamine, octadecylsilane, graphitized carbon black, strong anion exchange, and florisil. Extracted 3\u2010chloro\u20101,2\u2010propanediol was derivatized with heptafluorobutyric anhydride and subjected to gas chromatography\u2010mass spectrometry. This method had good linearity (correlation coefficients\u00a0&gt;0.99) in the range of 2\u20132000\u00a0ng\/g for blood, kidney, liver, testis, and brain samples. The limits of detection were under 0.8\u00a0ng\/g; the limits of quantification were 2\u00a0ng\/g; the recovery rates were 85%\u2013102%; and the matrix effects were 1.98%\u20137.67%. This method also had good precision. The dynamic changes in 3\u2010chloro\u20101,2\u2010propanediol in rats gavaged with 20\u00a0mg\/kg b.w. for 24\u00a0h were detected using this method. The 3\u2010chloro\u20101,2\u2010propanediol content in each tissue sharply increased to a peak, rapidly decreased within 2\u00a0h, and stabilized at 12\u00a0h. 3\u2010Chloro\u20101,2\u2010propanediol persisted in the kidney, testis, and liver 24\u00a0h after gavage.\n                  <\/jats:p>","DOI":"10.1002\/jssc.202200910","type":"journal-article","created":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:31:29Z","timestamp":1680309089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Determination of 3\u2010chloro\u20101,2\u2010propanediol in biological samples by quick\u2010easy\u2010cheap\u2010effective\u2010rugged\u2010and\u2010safe extraction coupled with gas chromatography\u2010mass spectrometry and its biodistribution in rats"],"prefix":"10.1002","volume":"46","author":[{"given":"Lei","family":"Lv","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering Shandong Academy of Sciences, Qilu University of Technology  Jinan P. 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