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Among which are combinations of proton pump inhibitors (e.g., omeprazole), histamine\u20102 receptor antagonists (e.g., famotidine), along with antibiotics (e.g., amoxicillin). In this work, a sensitive and accurate high\u2010performance thin\u2010layer chromatographic method was developed for the simultaneous determination of amoxicillin, metronidazole, and famotidine in bulk powder and laboratory\u2010prepared combined\u2010tablet mixtures. Complete separation of the cited compounds was achieved using pre\u2010coated silica gel plates with a mixture of methanol:chloroform:toluene:water:glacial acetic acid (5:2:1.5:0.5:0.1 v\/v\/v\/v\/v) as the mobile phase. The method was fully validated as per the international conference of harmonization guidelines. Good linearity, a correlation coefficient of 0.9991, was obtained in the concentration ranges 0.1\u20131.6\u00a0\u03bcg\/band (amoxicillin), 0.1\u20130.9\u00a0\u03bcg\/band (metronidazole), and 0.1\u20130.9\u00a0\u03bcg\/band (famotidine). Since the method allowed the determination of the three compounds in combined tablets with a high degree of selectivity, accuracy, precision, with cost\u2010effectiveness, it could be used for regular quality control. Moreover, the applicability of the proposed method was extended to the determination of the ternary mixture in simulated gastric juice. Method greenness was assessed using different green metrics.<\/jats:p>","DOI":"10.1002\/jssc.202200951","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T10:39:00Z","timestamp":1671187140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An eco\u2010friendly multi\u2010analyte high\u2010performance thin layer chromatographic densitometric determination of amoxicillin, metronidazole, and famotidine in their ternary mixtures and simulated gastric juice: A promising protocol for eradicating <i>Helicobacter pylori<\/i>"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3233-3657","authenticated-orcid":false,"given":"Marwa A. 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