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Inspired by the advantages of core\u2010shell materials, we fabricated a core\u2010shell material using amino\u2010functionalized silica as the core. Benzene\u20101,3,5\u2010tricarbaldehyde and 3,5\u2010diaminobenzoic acid were used as model organic ligands to construct a shell coating by alternately reacting the two monomers on the surface of silica microspheres. The resultant material featured an outstanding capability for the adsorption of cationic peptides, most likely owing to its porous structure, a large number of carboxylic functional groups, and low mass\u2010transfer resistance. The maximum saturated adsorption capacity reached 833.3\u00a0mg\/g and the adsorption process took only 20\u00a0min. Under optimized adsorption conditions, the core\u2010shell material was used to selectively adsorb cationic peptides from the tryptic digestive solution of lysozyme and bovine serum albumin, Specifically, the analysis results showed seven cationic peptides in the eluate and twenty anionic peptides in the supernatant, which indicates the efficient trap of most cationic peptides in the digestive solution.<\/jats:p>","DOI":"10.1002\/jssc.202201057","type":"journal-article","created":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T12:33:06Z","timestamp":1681043586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of core\u2010shell material rich in carboxyl groups and its application in the selective adsorption of cationic peptides"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4772-9731","authenticated-orcid":false,"given":"Shadi Ali Hassen","family":"Ahmed","sequence":"first","affiliation":[{"name":"Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province School of Chemistry &amp; Chemical Engineering Shaanxi Normal University  Xi'an P. 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