{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:14Z","timestamp":1786978154116,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Cilnidipine is a calcium channel blocker that is used to treat cardiac diseases such as angina and high blood pressure. Several column and planar chromatographic methods for estimating cilnidipine in pharmaceutical dosage forms have been documented. However, these method\u00a0developments have been carried out employing organic solvents such as acetonitrile, methanol, toluene, chloroform, and others as mobile phase components or as sample pretreatment diluents. These organic solvents are neurotoxic and teratogenic to humans and aquatic animals, according to International Council for Harmonization Q3C (R8) recommendations. According to the green analytical chemistry approach, such organic solvents should be reduced or removed during the development of chromatographic methods for environmental protection and the safety of human and aquatic animal life. As a result, the stability\u2010indicating chromatographic estimation of cilnidipine was performed utilizing less toxic organic solvents. To prevent organic solvent waste during method development, mobile\u2010phase optimization was performed using the design of experiment\u2010based response surface modeling. Cilnidipine has been subjected to hydrolysis, oxidation, photolysis, and dry\u2010heat decomposition to determine its stability. The greenness profiles of the suggested and published chromatographic methods were examined using the national environment method index, analytical greenness calculator, green analytical procedure index software, and eco\u2010scale assessment tool.<\/jats:p>","DOI":"10.1002\/jssc.202300332","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T23:56:58Z","timestamp":1689983818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Green analytical chemistry\u2010driven response surface modeling to stability\u2010indicating chromatographic method for estimation of cilnidipine and application of high\u2010performance thin\u2010layer chromatography\u2013mass spectrometry for characterization of degradation products"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-2087","authenticated-orcid":false,"given":"Pintu","family":"Prajapati","sequence":"first","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veera Shakar","family":"Pulusu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Ohio University Anthens Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance Maliba Pharmacy College Surat Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Council for Harmonization Q3C (R8). Impurities: guideline for residual solvent.2016."},{"key":"e_1_2_9_3_1","unstructured":"Indian Pharmacopoeia.Residual solvents the Indian Pharmacopeia Commission.2018."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40508\u2010016\u20100051\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsab097"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsac025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12247\u2010020\u201009506\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12247\u2010020\u201009490\u2010w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/1006.2018.31.6.8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmac055"},{"issue":"1","key":"e_1_2_9_11_1","first-page":"239","article-title":"Chemometric\u2010based AQbD and Green Chemistry approach to the chromatographic analysis of remogliozin etabonate and vildagliptin","volume":"106","author":"Ahir H","year":"2023","journal-title":"J AOAC Int"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsac107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsac086"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsad016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoacint\/qsac056"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200731"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200754"},{"issue":"11","key":"e_1_2_9_18_1","first-page":"1","article-title":"White analytical chemistry\u2010driven stability\u2010indicating concomitant chromatographic estimation of thiocolchicoside and aceclofenac using response surface analysis and red, green, and blue model","volume":"46","author":"Pulusu VS","year":"2023","journal-title":"J Sep Sci"},{"key":"e_1_2_9_19_1","unstructured":"DRUGBANK.Drug profile of cilnidipine.https:\/\/go.drugbank.com\/drugs\/DB09232"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v10i1.3846"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"296","article-title":"Development and validation of rapid stability indicating the chromatographic determination of cilnidipine in bulk and dosage form","volume":"6","author":"Mohammed SM","year":"2013","journal-title":"Res J Pharm Tech"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.53879\/id.55.12.11185"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/461461"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2020.00427.8"},{"key":"e_1_2_9_25_1","first-page":"6","article-title":"Stability indicating simultaneous validation of telmisartan, cilnidipine and chlorthalidone with forced degradation behaviour study by RP\u2010HPLC in the tablet dosage form","volume":"7","author":"Sharma A","year":"2016","journal-title":"Int J Chem Pharma Sci"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijpi.2022.3.51"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202300332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:49:29Z","timestamp":1760878169000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.202300332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":25,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jssc.202300332"],"URL":"https:\/\/doi.org\/10.1002\/jssc.202300332","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"assertion":[{"value":"2023-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300332"}}