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This study reports the development and validation of cost\u2010effective, simple, precise, accurate, and robust high\u2010performance liquid chromatography (HPLC) for the determination of clarithromycin (CLA) in tablets. Reversed\u2010phase chromatography was conducted using a standard column at 55\u00b0C with ultraviolet detection at 215\u00a0nm. A mobile phase consisting of acetonitrile \u20132\u2010methyl\u20102\u2010propanol \u2013potassium phosphate buffer was used at a flow rate of 1.0\u00a0mL\/min. The proposed method displayed good linearity, precision, accuracy, robustness, and specificity. The present HPLC was compared with capillary electrophoresis and bioassay methods and the results indicated that there was no significant difference between these methods. Moreover, the obtained results demonstrated the validity of the isocratic HPLC, which allows reliable quantitation of CLA in pharmaceutical samples. Thus, it can be used as a substitute alternative methodology for the routine quality control of this medicine, in situations where other methods are less accessible in the laboratory.<\/jats:p>","DOI":"10.1002\/jssc.202300424","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T04:45:09Z","timestamp":1693457109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Development and validation of high\u2010performance liquid chromatography method for determination of clarithromycin in pharmaceutical tablets"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-4746","authenticated-orcid":false,"given":"Abdelghani","family":"Mahmoudi","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science University of August 20th 1955\u2010Skikda  Skikda Algeria"},{"name":"Research Laboratory on Bioactive Products and Biomass Valorization (LRPBVB) Ecole Normale Sup\u00e9rieure\u2013Kouba  Algiers Algeria"},{"name":"Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Pharmaceutical Analysis University of Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"De Francia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, Clinical Pharmacology, Faculty of Medicine, S. 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