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Additionally, when the chain length is large enough, multiple charged species are formed, further complicating the mass spectra and processing. This study uses the advanced oligomer separation provided by supercritical fluid chromatography with a mass spectrometry approach that selectively ionizes poly(ethylene glycols) as ammoniated molecules to simplify data analysis and facilitate batch\u2010to\u2010batch comparisons. Several visual representations of the response of the ionization events based on the polymer molecular weight and the repeating unit were used to elucidate trends in ionization. Evaluation of the influence of the oligomer length and end\u2010group on the electrospray ionization of the polymer allowed the development of a process to enable selective ionization for these complex polymers.<\/jats:p>","DOI":"10.1002\/jssc.202300425","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T04:39:08Z","timestamp":1692765548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlling the positive ion electrospray ionization of poly(ethylene glycols) when using ultra\u2010high\u2010performance supercritical fluid chromatography\u2010mass spectrometry"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-4244","authenticated-orcid":false,"given":"Sergio","family":"Cancho\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Faculty of Engineering &amp; Physical Sciences School of Chemistry University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ferguson","sequence":"additional","affiliation":[{"name":"New Modalities &amp; Parenteral Development, Pharmaceutical Technology &amp; Development Operations, AstraZeneca  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Herniman","sequence":"additional","affiliation":[{"name":"Faculty of Engineering &amp; Physical Sciences School of Chemistry University of Southampton  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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