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Previous reports indicate that conventional high\u2010performance liquid chromatography (HPLC) analytical methods have proven inefficient performance in comprehensively characterizing components in <jats:italic>Valeriana jatamansi<\/jats:italic>. In the present study, a hybrid online analytical platform combining supercritical fluid extraction with both conventional HPLC separation (reverse phase) and supercritical fluid chromatography (normal phase) has been established and validated. This system can provide online extraction with two different chromatographic separation modes to increase separation ability and has been connected to a mass spectrometer to acquire high\u2010resolution mass spectrometry data. Then, the online platform was applied to screening components in <jats:italic>Valeriana jatamansi<\/jats:italic>. A total of 117 compounds were identified, including five lignans, 18 organic acids, six flavonoids, and 88 iridoids. Thirty\u2010three compounds were reported from <jats:italic>Valeriana jatamansi<\/jats:italic> for the first time. These results enrich our understanding of the components of <jats:italic>Valeriana jatamansi<\/jats:italic> and prove that the developed online platform in this study is a robust approach for accelerating working efficiency in comprehensively analyzing complicated samples.<\/jats:p>","DOI":"10.1002\/jssc.202300550","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T23:09:31Z","timestamp":1702076971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Simultaneously characterization of multiple constituents in <i>Valeriana jatamansi<\/i> Jones using an online supercritical fluid extraction\u2010high\u2010performance liquid chromatography\/supercritical fluid chromatography\u2010mass spectrometry system"],"prefix":"10.1002","volume":"47","author":[{"given":"Haochang","family":"Chen","sequence":"first","affiliation":[{"name":"Shimadzu (China) Co., Ltd.  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