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The separation was achieved using a developing system that includes chloroform:methanol:ethyl acetate:ammonia (6:2:2:0.2 by volume) as a mobile phase and the bands were detected at 240\u00a0nm. The concentration ranges were 5\u201325, 1\u20137, and 1\u20133.5\u00a0\u03bcg\/band for bisoprolol fumarate, carvedilol, and furosemide, respectively. This chromatographic approach is the first methodology for simultaneously determining bisoprolol fumarate, carvedilol, and furosemide in their pure forms and in their pharmaceutical dosage forms. The advantages of using known analytical procedures are their simplicity, speed, cost effectiveness, lack of laboriousness, and ability to save time as the three tablets are determined in one step and can be used for routine analysis of the investigated combinations in quality control laboratories. According to International Conference of Harmonization guidelines, the established procedures have been validated, and the results were statistically compared to those obtained by the reported reversed\u2010phase\u2013high\u2010performance liquid chromatography methods using Student's <jats:italic>t<\/jats:italic>\u2010test and <jats:italic>F<\/jats:italic>\u2010test, with no significant difference between them, indicating that the proposed methods can be used for routine drug quality control analysis.<\/jats:p>","DOI":"10.1002\/jssc.202300608","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T23:09:28Z","timestamp":1702076968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The improvement of routine drug quality control analysis of some antihypertensive drugs using high\u2010performance thin\u2010layer chromatography densitometry method with greenness profile evaluation"],"prefix":"10.1002","volume":"47","author":[{"given":"Nessreen S.","family":"Abdelhamid","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eglal A.","family":"Abdelaleem","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Lashien","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Nahda University  Sharq El Nile Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-5267","authenticated-orcid":false,"given":"Mahmoud M.","family":"Amin","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Nahda University  Sharq El Nile Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salwa I.","family":"Tohamy","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1986.tb02890.x"},{"key":"e_1_2_10_3_1","unstructured":"British Pharmacopoeia.Her Majesty's stationery office. 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