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In multiclass, multiresidue analysis of veterinary drugs, it is challenging to find one type of filter membrane that does not retain at least some of the analytes before injection in ultrahigh\u2010performance liquid chromatography\u2010tandem mass spectrometry (UHPLC\u2010MS\/MS). In this study, different filter membranes were tested for use in UHPLC\u2010MS\/MS analysis of 183 diverse drugs in bovine muscle, kidney, and liver tissues. Membranes evaluated consisted of polytetrafluoroethylene (PTFE), polyvinylidene difluoride (PVDF), polyethersulfone, nylon, and regenerated cellulose. Drug classes represented among the analytes included \u03b2\u2010agonists, \u03b2\u2010lactams, anthelmintics, macrolides, tetracyclines, sulfonamides, tranquilizers, (fluoro)quinolones, anti\u2010inflammatories, nitroimidazoles, coccidiostats, phenicols, and others. Although the presence of a matrix helped reduce the binding of analytes on surface active sites, all of the filter types partially retained at least some of the drugs in the final extracts. In testing by flow\u2010injection analysis, all of the membrane filters were also observed to leach interfering components. Ultimately, filtration was avoided altogether in the final sample preparation approach known as the quick, easy, cheap, effective, rugged, safe, efficient, and robust (QuEChERSER) mega\u2010method, and ultracentrifugation was chosen as an alternative.<\/jats:p>","DOI":"10.1002\/jssc.202300696","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T01:00:00Z","timestamp":1707958800000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of filter membranes in the analysis of 183 veterinary and other drugs by liquid chromatography\u2010tandem mass spectrometry"],"prefix":"10.1002","volume":"47","author":[{"given":"Nicol\u00e1s","family":"Michlig","sequence":"first","affiliation":[{"name":"US Department of Agriculture Agricultural Research Service Eastern Regional Research Center  Wyndmoor Pennsylvania USA"},{"name":"Programa de Investigaci\u00f3n y An\u00e1lisis de Residuos y Contaminantes Qu\u00edmicos (PRINARC) Facultad de Ingenier\u00eda Qu\u00edmica Universidad Nacional del Litoral  Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5934-7469","authenticated-orcid":false,"given":"Steven J.","family":"Lehotay","sequence":"additional","affiliation":[{"name":"US Department of Agriculture Agricultural Research Service Eastern Regional Research Center  Wyndmoor Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Lightfield","sequence":"additional","affiliation":[{"name":"US Department of Agriculture Agricultural Research Service Eastern Regional Research Center  Wyndmoor Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1541-4337.12702"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109141"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-018-1195-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2017.03.045"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2015.12.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.14227\/DT270420P6"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Modern filtration methods for HPLC and UHPLC sample preparation","volume":"20","author":"Pall Laboratory","year":"2019","journal-title":"LCGC and Cannabis Sci Technol"},{"key":"e_1_2_8_9_1","article-title":"Syringe filter suitability for sample preparation in drug assays","author":"Zhao L","year":"2013","journal-title":"Agilent Appl"},{"key":"e_1_2_8_10_1","first-page":"82","article-title":"Why analyte binding to syringe filters must be studied during filter validation for QC testing","volume":"23","author":"Joshi V","year":"2020","journal-title":"Am Pharm Rev"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/38.2.77"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.01.096"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2018.12.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12550-020-00405-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR08693B"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b03882"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14227\/DT150408P20"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200282"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200088"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.22670"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9RA06198C"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2006.01.008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01981"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4628(19991121)74:8<2046::AID-APP20>3.0.CO;2-3"},{"key":"e_1_2_8_25_1","unstructured":"FinneranJG.Two\u2010piece vial assembly. 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