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The method was linear in the range of 4\u2013150 and 5\u2013120\u00a0\u03bcg\/mL for TRP and DPH, respectively. The method was successfully applied for the simultaneous determination of DPH and TRP in a laboratory\u2010prepared gel containing all possible excipients with mean percent recoveries\u00a0\u00b1\u00a0standard deviation of 100.346\u00a0\u00b1\u00a01.265 and 100.754\u00a0\u00b1\u00a01.117 for TRP and DPH, respectively. The method was validated according to the International Conference on Harmonization guidelines. 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