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However, a specific and high\u2010throughput extraction method for AOH is currently lacking. Thus, developing an efficient pre\u2010treatment technique for AOH detection is extremely vital. Here, a novel automated magnetic solid\u2010phase extraction method was proposed for the highly efficient extraction of AOH. Combining the aptamer\u2010functionalized magnetic nanoparticles (AMNPs) and the automatic purification instrument, AOH could be extracted in medicinal herbs in high throughput (20 samples) and a short time (30\u00a0min). The main parameters affecting extraction were optimized, and the method was finally carried out by incubation AMNPs with 3\u00a0mL of sample solution for 10\u00a0min, and then desorption in 75% methanol for liquid\u2010phase detection. Under optimal conditions, good reproducibility, stability, and selectivity were realized with an adsorption capacity of 550.84\u00a0ng\/mg. AOH extraction in three edible herbs showed good resistance to matrix interference with recovery rates from 86% to 111%. In combination with AMNPs and the automatic purification instrument, high\u2010throughput and labor\u2010free extraction of AOH in different complex matrices was achieved, which could be extended in other complex matrices.<\/jats:p>","DOI":"10.1002\/jssc.202300870","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T22:43:55Z","timestamp":1710283435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010throughput extraction and automatic purification of alternariol from edible and medicinal herbs based on aptamer\u2010functionalized magnetic nanoparticles"],"prefix":"10.1002","volume":"47","author":[{"given":"Ruiqi","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy College Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Institute of Quality Standard and Testing 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