{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:45:40Z","timestamp":1777052740301,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p>Postpartum hemorrhage can lead to a variety of maternal complications. Tao Hong Si Wu Decoction (THSWD) is a traditional Chinese medicine used for treating gynecological diseases. However, the active ingredients of THSWD and its pharmacological mechanism of treatment for postpartum blood stasis still remained unclear. In this study, 201 components were identified in THSWD ethanol extract using ultra\u2010performance liquid chromatography coupled with quadrupole\u2010time\u2010of\u2010flight mass spectrometry, including 59 terpenoids and volatile oil, 61 Phenylpropanoids, 41 flavonoids, 22 alkaloids, and other 18 components. A total of 45 active compounds were identified in the blood and 33 active compounds were identified in the uterine. Taking the common components into the blood and into the uterus combined with network pharmacology. It was demonstrated that the active compounds can bind to the core target with good affinity through molecular docking. The results of this study will provide a reference for the quality control and pharmacodynamic material base research of THSWD.<\/jats:p>","DOI":"10.1002\/jssc.202300871","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T22:43:50Z","timestamp":1710283430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ultra\u2010performance liquid chromatography\u2010quadrupole time\u2010of\u2010flight mass combined with UNIFI to study the mechanism of Tao Hong Si Wu Decoction in the treatment of postpartum blood stasis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7258-094X","authenticated-orcid":false,"given":"Mengdie","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqing","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Mu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linfeng","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuqing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula  Hefei China"},{"name":"Xin'an Medicine Key Laboratory of Chinese Ministry of Education, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-1612","authenticated-orcid":false,"given":"Lan","family":"Han","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula  Hefei China"},{"name":"Xin'an Medicine Key Laboratory of Chinese Ministry of Education, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiyin","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Anhui University of Chinese Medicine  Hefei China"},{"name":"Anhui Province Key Laboratory of Chinese Medicinal Formula  Hefei China"},{"name":"Xin'an Medicine Key Laboratory of Chinese Ministry of Education, Anhui University of Chinese Medicine  Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.JAA.0000657164.11635.93"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c17-00945"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(13)60108-9"},{"issue":"05","key":"e_1_2_9_5_1","first-page":"1625","article-title":"Effects of Taohong Siwu Decoction on the VEGF, NO expression and PI3K\/Akt pathway alterations in uterine tissue of postpartum rats with blood stasis syndrome","volume":"31","author":"Han L","year":"2016","journal-title":"China J Tradit Chin Med Pharm"},{"issue":"01","key":"e_1_2_9_6_1","first-page":"60","article-title":"Effect of Taohong Siwu Decoction on protein expression of RhoA, p\u2010RhoA, and PAI\u20101 in Rho\/ROCK pathway in Postpartum rats with blood stasis syndrome","volume":"33","author":"LI B","year":"2014","journal-title":"J Anhui Univ Chin Med"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00347"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115031"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202000498"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100664"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100624"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200678"},{"issue":"11","key":"e_1_2_9_13_1","first-page":"887","article-title":"Screening and identification of undeclared synthetic compounds as adulterants using UPLC\u2010QTOF\u2010MS coupled to a novel informatics platform","volume":"81","author":"Patel DN","year":"2015","journal-title":"Planta Med"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.01.047"},{"key":"e_1_2_9_15_1","article-title":"Traditional Chinese medicine\u2010based network pharmacology could lead to new multicompound drug discovery","volume":"12","author":"Li J","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-019-3064-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.10.059"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.09.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.02.022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113641"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12861"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmu155"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4032820"},{"issue":"12","key":"e_1_2_9_24_1","first-page":"1641","article-title":"Analysis and identification of glycosides in Paeonia lactiflora by UPLC\u2010MS\/MS","volume":"36","author":"Zheng M","year":"2011","journal-title":"China J Chin Mater Med"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23051070"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091157"},{"issue":"21","key":"e_1_2_9_27_1","first-page":"3702","article-title":"Analysis and identification of chemical constituents in Siwu decoction by UPLC\u2010Q\u2010TOF\u2010MS(E)","volume":"38","author":"Wang Z","year":"2013","journal-title":"China J Chin Mater Med"},{"issue":"11","key":"e_1_2_9_28_1","first-page":"1078","article-title":"High performance liquid chromatography\u2010mass spectrometry analysis of Radix Angelica Sciensis","volume":"41","author":"Yang F","year":"2006","journal-title":"Acta Pharmaceutica Sinica"},{"issue":"6","key":"e_1_2_9_29_1","first-page":"911","article-title":"Structure elucidation of degradation products of Z\u2010ligustilide by UPLC\u2010QTOF\u2010MS and NMR spectroscopy","volume":"48","author":"Zuo A","year":"2013","journal-title":"Acta Pharmaceutica Sinica"},{"issue":"1","key":"e_1_2_9_30_1","first-page":"55","article-title":"Lymphatic system in central nervous system","volume":"35","author":"Thomas JL","year":"2019","journal-title":"Med Sci"},{"issue":"1","key":"e_1_2_9_31_1","first-page":"88","article-title":"Comparative analysis of 9 constituents in processed products of Radix angelicae sinensis","volume":"28","author":"Tao Y","year":"2017","journal-title":"Tradit Chin Drug Res Clin Pharmacol"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.202300871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:14:38Z","timestamp":1760865278000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.202300871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jssc.202300871"],"URL":"https:\/\/doi.org\/10.1002\/jssc.202300871","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2300871"}}