{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:15:22Z","timestamp":1789694122414,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>Hua\u2010ju\u2010hong (HJH) is a Chinese medicinal material obtained from <jats:italic>Citrus grandis<\/jats:italic> \u2018Tomentosa\u2019 (CGT) and <jats:italic>Citrus grandis<\/jats:italic> (L.) Osbeck (CG) with various commercial specifications. It is known for relieving cough and dispelling phlegm. To reveal the quality marker for distinguishing the various HJH, 215 batches of commercial HJH were studied systematically using multidimensional chemical analysis. Ten major components were identified by high\u2010performance liquid chromatography coupled with quadrupole\u2010time\u2010of\u2010flight mass spectrometry and quantified via high\u2010performance liquid chromatography coupled with diode array detection. In this study, a rapid, efficient, and low\u2010cost chromatographic method was established. Total coumarin\u2010hemiterpene and total coumarin\u2010monoterpene were first classified and analyzed in HJH. The result indicated that the main component, naringin, was not the quality marker for differentiating CGT from CG. For reflecting the unique medicinal and food value of HJH, coumarins should be the more potential quality markers. Flavonoids were the possible quality markers for distinguishing two growth stages of fruit\u2010exocarp and young fruit. For the first time, two chemotypes of HJH were identified in CG. This study provides a convenient yet reliant chromatographic method and novel yet systematic strategies for overall quality control of commercial HJH.<\/jats:p>","DOI":"10.1002\/jssc.202400127","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:12:08Z","timestamp":1717153928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analytical strategies to identify multicomponent quality markers for commercial Hua\u2010ju\u2010hong using multidimensional chemical analysis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-0951","authenticated-orcid":false,"given":"Chuchu","family":"Zhong","sequence":"first","affiliation":[{"name":"Research Center for Traditional Chinese Medicine of Lingnan (Southern China) Jinan University  Guangzhou China"},{"name":"College of Pharmacy Jinan University  Guangzhou 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