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The CCOF\u2010TpPa\u2010Py@SiO<jats:sub>2<\/jats:sub> core\u2010shell composite was used as a chiral stationary phase for the separation of the racemates by high\u2010performance liquid chromatography, which exhibits good separation performance for chiral compounds including ketones, alcohols, esters, epoxides, carboxylic acids, amides, and amines. The effects of analyte injection mass on the enantioseparation were studied. The reproducibility and stability of the CCOF\u2010TpPa\u2010Py@SiO<jats:sub>2<\/jats:sub> chiral column were explored. The intra\u2010day (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), inter\u2010day (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), and inter\u2010column (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) relative standard deviations for the migration times and resolution of benzoin were 0.32%\u20130.54%, 0.45%\u20130.61%, and 1.21%\u20131.53%, respectively. In addition, the chiral separation ability of the CCOF\u2010TpPa\u2010Py@SiO<jats:sub>2<\/jats:sub> chiral column (column A) was compared with that of the MDI\u2010\u03b2\u2010CD\u2010Modified COF@SiO<jats:sub>2<\/jats:sub> (column B) as well as a commercial chiral column (Chiralpak AD\u2010H). The chiral recognition ability of column A is complementary to that of column B and AD\u2010H column. The resolution mechanism of CCOF\u2010TpPa\u2010Py@SiO<jats:sub>2<\/jats:sub> stationary phase towards chiral analyte was explored. Hence, the synthesis of CCOF\u2010TpPa\u2010Py@SiO<jats:sub>2<\/jats:sub> core\u2010shell composite by induction at room temperature as chiral stationary phases for chromatographic separation has important research potential and application prospects.<\/jats:p>","DOI":"10.1002\/jssc.202400140","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T03:00:47Z","timestamp":1722999647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Room temperature synthesis of a chiral covalent organic framework core\u2010shell composite for high\u2010performance liquid chromatography enantioseparation"],"prefix":"10.1002","volume":"47","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry Yunnan Normal University  Kunming P. R. 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