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Herein, a boric acid\u2010functionalized hypercrosslinked polymer was prepared and utilized as a sorbent for the dispersive solid\u2010phase extraction of CAs and their metabolites in rat serum. By combination with a high\u2010performance liquid chromatography\u2010fluorescence detector, the extraction parameters for the seven target analytes were optimized. Under the optimal extraction condition, the methodology for the quantitative analysis of CAs and their metabolites in rat serum samples was established. The limits of detection and limits of quantification were found to be in the ranges of 0.010\u20130.015 and 0.033\u20130.050\u00a0ng\/mL, respectively. The results demonstrated satisfactory recoveries, with values ranging from 88.02% to 113.27%, accompanied by relative standard deviations within the range of 2.69%\u20139.59%. In addition, the method showed good anti\u2010interference ability (matrix effect ranged from 2.64% to 18.07%). The developed method was validated for the determination of CAs and their metabolites in normal and Alzheimer's disease model rats\u2019 serum, which proved the promising application of the method for CAs neurotransmitter analysis in biological samples.<\/jats:p>","DOI":"10.1002\/jssc.202400418","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T23:09:58Z","timestamp":1726873798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Boric Acid Functionalized Hypercrosslinked Polymers for Selective Extraction of Trace Catecholamines and Their Metabolites in Rat Serum"],"prefix":"10.1002","volume":"47","author":[{"given":"Zhiyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Academy of Chinese Medicine Sciences &amp; Pharmacy College Henan University of Chinese Medicine  Zhengzhou 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