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The compound mixture investigated comprised caffeine, theobromine, theophylline, uracil, testosterone, and pyrene, diluted in methanol. Dynamic response ranges were evaluated with multiple injections at different concentrations. Precision studies demonstrated the robustness and sensitivity of the ionization source across a concentration range of 10\u20131000\u00a0ng\/mL. Results from this experiment showed linear regression of 0.99 or greater for all analytes tested over the range with a relative standard deviation (RSD) of less than 10% down to 10\u00a0ng\/mL for all analytes except theobromine, which had an RSD of less than 10% down to 25\u00a0ng\/mL. Notably, this study marks the first investigation of sensitivity for coupling a commercial DBDI source with SFC; a limit of detection less than 1\u00a0ng\/mL was achieved for all compounds. This study demonstrates chromatographic separation by SFC and MS analysis for compounds that ionize poorly using traditional atmospheric pressure ionization, such as polycyclic aromatic hydrocarbons. Combining SFC with the DBDI source opens promising avenues for analyzing compounds that were previously challenging to characterize with standard atmospheric pressure ionization techniques.<\/jats:p>","DOI":"10.1002\/jssc.202400500","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T06:14:54Z","timestamp":1727244894000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Characterization of a Soft Ionization by Chemical Reaction in Transfer Ion Source Hyphenated With Supercritical Fluid Chromatography\u2010Tandem Mass Spectrometry"],"prefix":"10.1002","volume":"47","author":[{"given":"Niray","family":"Bhakta","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Texas at Arlington  Arlington Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander 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