{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:56:16Z","timestamp":1790873776919,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022106061"],"award-info":[{"award-number":["H2022106061"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Guyinjian (GYJ) is a classic traditional Chinese medicine formula for the treatment of polycystic ovary syndrome, ovulation disorders, immuno\u2010sterility, oligomenorrhea with kidney deficiency, and so forth. Due to the unclear chemical components of GYJ, the elucidation of the pharmacological mechanism, and the comprehensive development and utilization of GYJ in clinical is being restricted. In this study, ultra\u2010high\u2010performance liquid chromatography with quadrupole time\u2010of\u2010flight\u2010tandem mass spectrometry combined with the Progenesis QI platform and using reference standards, online and self\u2010built databases matching, fragmentation rules analysis of mass spectrometry peaks, a total of 235 compounds were preliminarily characterized, including 69 flavonoids, 65 terpenoids, 34 phenylpropanoids, 22 saccharides, sugar esters, and glycosides, 15 organic acids, and 30 others. These compounds may reflect the chemical properties of GYJ. The method established in this study can systematically, rapidly, and accurately resolve the chemical components in GYJ, which lays the foundation for further establishment of the pharmacodynamic substance basis and quality control.<\/jats:p>","DOI":"10.1002\/jssc.70019","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T08:35:07Z","timestamp":1730882107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rapid Characterization of the Constituents in Classic Chinese Medicine Formula Guyinjian Using Ultra\u2010High\u2010Performance Liquid Chromatography With Quadrupole Time\u2010of\u2010Flight Mass Spectrometry"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5400-2552","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine National Chinmedomics Research Center National TCM Key Laboratory of Serum Pharmacochemistry Metabolomics Laboratory Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-9283","authenticated-orcid":false,"given":"Nan","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine National Chinmedomics Research Center National TCM Key Laboratory of Serum Pharmacochemistry Metabolomics Laboratory Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1381-9903","authenticated-orcid":false,"given":"Le","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome The Second Affiliated Hospital Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine National Chinmedomics Research Center National TCM Key Laboratory of Serum Pharmacochemistry Metabolomics Laboratory Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome The Second Affiliated Hospital Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangli","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integration and 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine National Chinmedomics Research Center National TCM Key Laboratory of Serum Pharmacochemistry Metabolomics Laboratory Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"State Key Laboratory of Dampness Syndrome The Second Affiliated Hospital Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238611"},{"key":"e_1_2_7_3_1","first-page":"87","article-title":"Effect of Gu Yin Decoction plus Reduction on Ovarian Reserve Function in Patients With Ovarian Hyporesponsiveness and Kidney Yin 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