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However, due to its complex composition, little attention has been given to the analysis of chemical components present in SWG. This study employs ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry (UHPLC\u2010QTOF\/MS) combined with gas chromatography\u2010mass spectrometry (GC\u2010MS) to provide a reliable and comprehensive method for characterizing the chemical components in SWG. By screening with high mass accuracy (&lt; 10 ppm) and comparing with literature and UHPLC\u2010MS\/MS online databases, the fragmentation pathways and characteristic fragments of some representative compounds were elucidated. A total of 138 compounds were successfully identified, including flavonoids, phenylpropanoids, organic acids, phenols, lignans, nucleosides, terpenoids, glycosides, and other plant chemicals. Then, the volatile compounds in SWG were characterized using GC\u2010MS combined with the NIST library, and a total of 14 compounds were putatively characterized. These findings not only help elucidate the material basis of the pharmacological actions of SWG, providing the necessary basis for the quality control and standardization of SWG, but also offer references for the separation of small\u2010molecule compounds. The science of traditional Chinese medicine separation is shifting from a \u201csingle\u2010component orientation\u201d to a focus that balances \u201cholism and precision.\u201d Modern technologies have significantly enhanced the efficiency and quality control of component separation.<\/jats:p>","DOI":"10.1002\/jssc.70144","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T05:00:04Z","timestamp":1746680404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Qualitative Analysis of Chemical Components in Shiqi Waigan Granules Using UHPLC\u2010QTOF\/MS and GC\u2010MS Technologies"],"prefix":"10.1002","volume":"48","author":[{"given":"Lin","family":"Feng","sequence":"first","affiliation":[{"name":"College of Pharmacy Changchun University of Chinese Medicine  Changchun China"},{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokang","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Fang","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"An","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Tang","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Peng","sequence":"additional","affiliation":[{"name":"Zhongshan Zhongzhi Pharmaceutical Group Co. 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