{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:58:52Z","timestamp":1790654332740,"version":"4.1.0"},"reference-count":89,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602902"],"award-info":[{"award-number":["2022YFC3602902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A growing concern has been raised about human exposure to phthalates and bisphenols, while data is limited regarding the accumulation of these endocrine disrupting chemicals at the target tissue. In this study, a novel, simple, and sensitive method was successfully developed for the simultaneous determination of nine phthalate monoesters and nine bisphenols in human prostate tissue samples. A solid\u2013liquid extraction procedure was applied following ultra\u2010high performance liquid chromatography tandem mass spectrometry analysis. The detection and quantification limits were in the range of 4.12 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    to 0.370\u00a0ng\/g and 1.38 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    to 1.23\u00a0ng\/g, respectively. The average spiked recoveries varied from 71.4% to 102%, with relative standard deviations \u2264 10%. Finally, this method was applied to 76 human prostate tissue samples. Four phthalate monoesters (mono\u2010ethyl phthalate, mono\u2010\n                    <jats:italic>iso<\/jats:italic>\n                    \u2010butyl phthalate, mono\u2010\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butyl phthalate, and mono\u2010benzyl phthalate) were detected with the highest frequency of 98.68%, followed by other five phthalate monoesters (71.05% \u223c 94.74%), bisphenol S (72.37%), and bisphenol A (57.89%). Five bisphenols were not detected in any tissue sample. The concentrations of detected phthalate monoesters and bisphenols ranged from 1.12 \u00d7 10\n                    <jats:sup>\u22123\u00a0<\/jats:sup>\n                    to 1.86 \u00d7 10\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0ng\/g and 6.08 \u00d7 10\n                    <jats:sup>\u22123\u00a0<\/jats:sup>\n                    to 39.0\u00a0ng\/g, respectively, with standard errors ranging from 3.25\u00d710\n                    <jats:sup>\u22123\u00a0<\/jats:sup>\n                    to 4.64\u00a0ng\/g. Besides, a positive correlation for the concentration of seven phthalate monoesters and bisphenol A could be observed between tissue and urine, which indicates that these metabolites in urine can serve as noninvasive biomarkers to evaluate the true exposure level of prostate tissue. This study provides data and information on exposure to phthalate monoesters and bisphenols in human prostate tissue and the association with their urinary metabolites, supporting further studies of pollutant exposure and prostate disease.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70154","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T05:47:12Z","timestamp":1745819232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Phthalate Monoesters and Bisphenols in Human Prostate Cancer Tissue and Urine"],"prefix":"10.1002","volume":"48","author":[{"given":"Tianai","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Public Health Laboratory Science West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan 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