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Indeed, current legislations impose that THC in hemp products must meet defined concentration limits or, in some cases, it must be completely removed. In the present study, the continuous depletion of THC has been performed through simulated moving bed chromatography operated with a fully green mobile phase, made of water and ethanol. This process permits to overcome the limits and drawbacks of available purification methods, based on toxic solvents and traditional single column chromatography.<\/jats:p>","DOI":"10.1002\/jssc.70175","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T07:34:54Z","timestamp":1747899294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Continuous Depletion of Tetrahydrocannabinol From\n                    <i>Cannabis<\/i>\n                    Extract Through Simulated Moving Bed Chromatography Using Green Mobile Phase"],"prefix":"10.1002","volume":"48","author":[{"given":"Greta","family":"Compagnin","sequence":"first","affiliation":[{"name":"Department of Environmental and Prevention Sciences University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Nosengo","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Greco","sequence":"additional","affiliation":[{"name":"KNAUER Wissenschaftliche Ger\u00e4te GmbH  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Catani","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Cavazzini","sequence":"additional","affiliation":[{"name":"Department of Chemical, Pharmaceutical and Agricultural Sciences University of Ferrara  Ferrara Italy"},{"name":"Council for Agricultural Research and Economics  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Krauke","sequence":"additional","affiliation":[{"name":"KNAUER Wissenschaftliche Ger\u00e4te GmbH  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Felletti","sequence":"additional","affiliation":[{"name":"Department of Environmental and Prevention Sciences University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01471-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-9936(87)87088-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC04387K"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690470915"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.11062"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461304"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.1c00520"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.465440"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464530"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2478\/acph-2021-0021"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11162130"},{"key":"e_1_2_11_13_1","unstructured":"J.Black R.Beigie andA.Mateo.CannabisExtracts. 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