{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:40:08Z","timestamp":1789342808568,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LGC21B050003"],"award-info":[{"award-number":["LGC21B050003"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21878064"],"award-info":[{"award-number":["21878064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A facile dispersive micro\u2010solid phase extraction (D\u2010\u03bc\u2010SPE) method that uses spherical cellulose aerogels is proposed herein for the trace detection of seven benzodiazepines in biological samples. Zirconium metal\u2013organic framework (MOF) particles were dispersed in the cellulose aerogels to improve the extraction efficiency. The prepared lightweight spherical aerogels (diameter of approximately 2\u00a0mm) were easily collected from the solution using a disposable dropper, overcoming the difficult recycling of powdered MOFs. The effect of the MOF loading (39, 56, and 66 wt%) and the organic ligand (terephthalic acid, 2\u2010aminoterephthalic acid, and 4,4\u2032\u2010biphenyldicarboxylic acid) in the Zr\u2010MOF on the extraction ability of the hybrid aerogels towards benzodiazepines was studied. The hybrid aerogel with a UiO\u201067 loading of 66% showed the best extraction performance primarily because of the enhanced surface area, pore volume, and \u03c0\u2013\u03c0 stacking interactions. Moreover, the UiO\u201067\/cellulose aerogel spheres were mechanically stable and showed reusability for at least eight consecutive extraction cycles. The main factors affecting extraction, such as solution pH, extraction time, type and volume of desorption solvent, and desorption time, were also examined. Under the optimal conditions, the limits of detection ranged from 0.01 to 0.03\u00a0\u00b5g\/L, and the limits of quantification ranged from 0.02 to 0.10\u00a0\u00b5g\/L. The recoveries were 81.8%\u2013104.2% for urine samples and 81.5%\u201399.5% for hair samples. The results suggest that the spherical aerogel\u2010based D\u2010\u03bc\u2010SPE is a simple and effective method for the quantification of benzodiazepines in biological samples.<\/jats:p>","DOI":"10.1002\/jssc.70221","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:28:18Z","timestamp":1751887698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lightweight Spherical Cellulose Aerogels With High Zr\u2010MOF Loadings for the Facile Extraction of Benzodiazepines From Human Urine and Hair Samples"],"prefix":"10.1002","volume":"48","author":[{"given":"Suling","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengli","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Criminal Science and Technology Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Ying","sequence":"additional","affiliation":[{"name":"Institute of Criminal Science and Technology Public Security Bureau of Hangzhou  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongting","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"994","article-title":"Analytical Methods for Determination of Benzodiazepines. 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