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However, their excessive use can lead to adverse effects in humans. Therefore, rapid and accurate analysis of these inhibitors in whole blood samples is crucial for public health, although this presents significant challenges. In this study, perfluorooctyl\u2010functionalized halloysite nanotubes were synthesized and used as sorbents for dispersive solid\u2010phase extraction. The developed sorbents interacted with inhibitors through various mechanisms, including hydrophobic interactions, electrostatic interactions, F\u2013\u03c0 interactions, and hydrogen bonding. Notably, their adsorption capacity was twice that of unmodified halloysite nanotubes. By combining the perfluorooctyl\u2010functionalized halloysite nanotubes\u2010based dispersive solid\u2010phase extraction method with liquid chromatography\u2010tandem mass spectrometry, an analytical method was developed to determine concentrations of the three inhibitors in whole blood samples. Under optimized conditions, the limits of detection ranged from 1.2 to 2.1 ng\/mL. The recoveries achieved 91.9%\u2013101.5% for intra\u2010day and 92.8%\u2013101.2% for inter\u2010day. The inter\u2010 and intra\u2010day relative standard deviations were in the range of 0.6%\u20133.8% and 2.3%\u20138.1%, respectively. This study introduces a novel approach for developing sorbents to target drugs and presents an innovative analytical method for therapeutic monitoring. These advancements will facilitate the evaluation of the pharmacokinetics of these inhibitors in patients and support ongoing clinical trials.<\/jats:p>","DOI":"10.1002\/jssc.70226","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T08:20:20Z","timestamp":1752308420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of Perfluorooctyl\u2010Functionalized Halloysite Nanotubes for Dispersive Solid\u2010Phase Extraction of Antimalarial Inhibitors in Whole Blood"],"prefix":"10.1002","volume":"48","author":[{"given":"Kejie","family":"Wang","sequence":"first","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingye","family":"Shi","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Hebei University  Baoding 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