{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:45:13Z","timestamp":1764665113520,"version":"3.46.0"},"reference-count":47,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this work, the preparation of a low\u2010swelling mercaptopropyltrimethoxysilane (MPTMS)\u2010modified polydivinylbenzene micropheres matrix for cinchona chiral stationary phases is reported. It was found that MPTMS preferentially deposits within the smaller pores of PDVB particles during the sol\u2013gel process, leading to an increased average pore size and a narrower pore size distribution. The swelling resistance of the particles increased in proportion to the amount of MPTMS that was loaded. The measured swelling propensity (SP) value for PDVB\u20105SH\u2010QN in methanol and acetonitrile are 0.097 and 0.226, respectively, which are considerably lower than the values of 0.759 and 1.142 obtained for polydivinylbenzene microspheres. The performance of the chiral column was evaluated using a sample set containing 20 FMOC\u2010amino acids. The results indicated that the modification of organosilane led to enhancements in column efficiency. The mass transfer resistance coefficient in the Van Deemter equation for PDVB\u20105SH\u2010QN (\n                    <jats:italic>C<\/jats:italic>\n                    = 1.86 \u00b5s; standard error = 0.11) is comparable to that for SiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010QN (\n                    <jats:italic>C<\/jats:italic>\n                    = 2.74 \u00b5s; standard error = 0.13). The enantioselectivity exhibited by the column is analogous to that observed in SiO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010QN. Under alkaline mobile phase conditions, the polymer\u2010based stationary exhibited excellent stability and reproducibility.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70236","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T04:14:33Z","timestamp":1754540073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Stable Cinchona Chiral Stationary Phase Based on Mercaptopropylsilane Modified Polydivinylbenzene Microspheres"],"prefix":"10.1002","volume":"48","author":[{"given":"Mingming","family":"Cao","sequence":"first","affiliation":[{"name":"Engineering Research Center of Pharmaceutical Process Chemistry School of Pharmacy Ministry of Education East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Pharmaceutical Process Chemistry School of Pharmacy Ministry of Education East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Pharmaceutical Process Chemistry School of Pharmacy Ministry of Education East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxiong","family":"Ke","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Pharmaceutical Process Chemistry School of Pharmacy Ministry of Education East China University of Science and Technology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.08.155"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.463934"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.464328"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462229"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463711"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26082396"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6NR06862F"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00396-007-1705-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12182-008-0062-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.200300015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14237431"},{"issue":"1","key":"e_1_2_7_13_1","first-page":"1","article-title":"Composites of Silica Aerogels With Organics: A Review of Synthesis and Mechanical Properties","volume":"57","author":"Lee K.\u2010Y.","year":"2019","journal-title":"Journal of the Korean Chemical Society"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0263617417694364"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10450-015-9741-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2010.07.006"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.09.090"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/la303813q"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10601325.2019.1698961"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2015.06.050"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202400462"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201202810"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337-017-3349-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462069"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23237"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.11.008"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.07.109"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.10.086"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.12.059"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202400369"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(96)00137-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac801384f"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02490555"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.12.078"},{"key":"e_1_2_7_35_1","first-page":"174","article-title":"Automated and Simultaneous Two\u2010Dimensional Micro\u2010High\u2010Performance Liquid Chromatographic Determination of Proline and Hydroxyproline Enantiomers in Mammals","volume":"875","author":"Tojo Y.","year":"2008","journal-title":"Journal of Chromatography A"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.05.024"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.06.094"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.08.010"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.08.004"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1997)9:2<157::AID-CHIR15>3.0.CO;2-M"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)93514-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.06.045"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0956-9618(95)00126-3"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(90)85174-T"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00174a007"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.10.090"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9914824"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/aic.690370606"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:42:23Z","timestamp":1764664943000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jssc.70236"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70236","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"type":"print","value":"1615-9306"},{"type":"electronic","value":"1615-9314"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70236"}}