{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:45:19Z","timestamp":1764665119770,"version":"3.46.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    An analytical method was developed and validated for the simultaneous detection of four glycol ethers in cosmetic creams using headspace gas chromatography coupled with mass spectrometry (HS\u2010GC\u2013MS). Samples were extracted with ethanol and then subjected to vortexing and ultrasonic treatment prior to analysis. The analytes showed good linearity within the concentration range of 25\u2013200\u00a0\u00b5g\/mL, with determination coefficients (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    ) exceeding 0.995. Limits of detection (LOD) and quantification (LOQ) were determined for each compound. For ethylene glycol dimehyl ether (EGDME), LOD and LOQ were 1.39 and 4.00\u00a0\u00b5g\/mL, respectively. For diethylene glycol monoethyl ether (DEGEE), values were 3.70 and 12.34\u00a0\u00b5g\/mL. Triethylene glycol dimethyl ether (TEGDME) showed LOD and LOQ of 1.61 and 5.38\u00a0\u00b5g\/mL. For phenoxyethanol (EGPhE), these limits were 4.79 and 15.95\u00a0\u00b5g\/mL. Mean recovery rates ranged from 96.72% to 100.40%, and relative standard deviations (RSDs) remained below 15% across all validation procedures. The average method recovery ranged between 100.34% and 102.09%. The validation parameters, including specificity, linearity, precision, trueness, and accuracy, were found to be satisfactory.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70243","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:55:42Z","timestamp":1754384142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and Validation of a Headspace Gas Chromatography\u2013Mass Spectrometry Method for the Identification and Quantification of Glycol Ethers in Cosmetic Cream Formulations"],"prefix":"10.1002","volume":"48","author":[{"given":"Imane","family":"Mecheri","sequence":"first","affiliation":[{"name":"Toxicology Laboratories Faculty of Medicine Department of Pharmacy Salah Boubnider Constantine 3 University Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Djafer","sequence":"additional","affiliation":[{"name":"Toxicology Laboratories Faculty of Medicine Department of Pharmacy Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Dammak","sequence":"additional","affiliation":[{"name":"Total Testing Services, BP 53 Technopole Industrial Zone  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahma Ben","family":"Slama","sequence":"additional","affiliation":[{"name":"Total Testing Services, BP 53 Technopole Industrial Zone  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Habib","family":"Belmahi","sequence":"additional","affiliation":[{"name":"Toxicology Laboratories Faculty of Medicine Department of Pharmacy Salah Boubnider Constantine 3 University Constantine Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"ANSM \u00c9valuation du Risque li\u00e9 \u00e0 l'utilisation du Ph\u00e9noxy\u00e9thanol Dans les Produits Cosm\u00e9tiques Saisine 2009BCT0058bis (ANSM 2012)."},{"key":"e_1_2_8_3_1","unstructured":"Y.CohenandC.Gleitz \u201cLes conservateurs dans les produits cosm\u00e9tiques: cas des parab\u00e8nes et du ph\u00e9noxy\u00e9thanol. Et que penser des produits cosm\u00e9tiques 'biologiques'?\u201d (master's thesis DUMAS 2009). dumas\u201001300549."},{"volume-title":"Ethers de glycol\u00a0: Quels risques pour la sant\u00e9\u00a0?","year":"1999","author":"INSERM","key":"e_1_2_8_4_1"},{"key":"e_1_2_8_5_1","unstructured":"\u201c2\u2010Ph\u00e9noxy\u00e9thanol (122\u201099\u20106) | PSC \u201dINERIS cited April 6 2024 https:\/\/substances.ineris.fr\/substance\/122\u201099\u20106."},{"key":"e_1_2_8_6_1","unstructured":"AFSSET (French Agency for Environmental and Occupational Health Safety)Les \u00c9thers de Glycol. Synth\u00e8se des Connaissances sur les Expositions de la Population G\u00e9n\u00e9rale et Professionnelle en France Rapport Saisine no 2003\/016 (Afsset 2008) https:\/\/www.anses.fr\/en\/system\/files\/CHIM2003et0016Ra\u20103.pdf."},{"key":"e_1_2_8_7_1","unstructured":"\u201cLes \u00c9thers de Glycol\u2014Fiche Solvants ED 4222 \u201d INRS 2011 https:\/\/www.inrs.fr\/media.html?refINRS=ED%204222."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370\u2010022\u201000462\u20102"},{"key":"e_1_2_8_9_1","article-title":"Annexe II du D\u00e9cret ex\u00e9cutif n\u00b010\u2010114. Liste des substances qui ne peuvent entrer dans la composition des produits cosm\u00e9tiques et d'hygi\u00e8ne corporelle. R\u00e9glementation","volume":"26","author":"Minist\u00e8re du Commerce Alg\u00e9rie","year":"2021","journal-title":"Journal Officiel de la R\u00e9publique Alg\u00e9rienne"},{"key":"e_1_2_8_10_1","article-title":"Annexe III du D\u00e9cret ex\u00e9cutif n\u00b010\u2010114. Liste des substances que les produits cosm\u00e9tiques et d'hygi\u00e8ne corporelle ne peuvent contenir en dehors des restrictions et conditions pr\u00e9vues. R\u00e9glementation","volume":"26","author":"Minist\u00e8re du Commerce Alg\u00e9rie","year":"2021","journal-title":"Journal Officiel de la R\u00e9publique Alg\u00e9rienne"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201701542"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.11.121"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.08.042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600180"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01278-5"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.12-198"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600904"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxac.2017.09.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2003.07.012"},{"issue":"11","key":"e_1_2_8_20_1","article-title":"Miniaturized Sample Preparation Methods to Simultaneously Determine the Levels of Glycols, Glycol Ethers and Their Acetates in Cosmetics","volume":"3","author":"Celeiro M.","year":"2021","journal-title":"Separation Science Plus"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T08:42:37Z","timestamp":1764664957000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jssc.70243"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70243","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"type":"print","value":"1615-9306"},{"type":"electronic","value":"1615-9314"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70243"}}