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Two new methods for the determination of chlorophylls and \u03b2\u2010carotene were developed here, one based on in\u2010tube solid\u2010phase microextraction (IT\u2010SPME) coupled online to nanoliquid chromatography (nanoLC) with diode array detection (DAD), and the other on ultraviolet\u2010visible diffuse reflectance spectroscopy (UV\u2010vis DRS). A protocol to extract the pigments from spirulina was proposed using ethanol (1.5\u00a0mL). The aim is to provide fast and environmentally friendly techniques for both the extraction and measurement of pigments, generating little waste and low energy expenditure. IT\u2010SPME\u2010nanoLC\u2010DAD and UV\u2010vis DRS showed good linearity up to 300 or 600 \u00b5g\/L and 50 mg\/L, with instrumental detection limits between 10 and 50 \u00b5g\/L and 2 and 5 mg\/L, respectively. The % intraday and interday relative standard deviation were between 2 and 9. The HEXAGON tool is used for assessing greenness and sustainability for three scenarios: establishing composition, quality control, and comparison of seven dietary supplements<\/jats:p>","DOI":"10.1002\/jssc.70260","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T03:34:04Z","timestamp":1757561644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chlorophylls and \u03b2\u2010carotene in <i>Spirulina platensis<\/i> Dietary Supplements: Nano Liquid Chromatography Versus Diffuse Reflectance Spectroscopy for Establishing Composition, Quality Control, and Comparison of Commercial Products"],"prefix":"10.1002","volume":"48","author":[{"given":"C.","family":"Soto","sequence":"first","affiliation":[{"name":"Departament de Qu\u00edmica Anal\u00edtica, Facultat de Qu\u00edmica MINTOTA Research Group, Universitat De Val\u00e8ncia  Burjassot 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