{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:40:00Z","timestamp":1787892000125,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Matrix effects in gas chromatography (GC) are typically regarded as an analytical drawback, as co\u2010eluting compounds can distort analyte quantification. This study demonstrates that a transient matrix effect can be deliberately induced to enhance GC\u2013MS sensitivity for environmental pollutants. Four classes of high\u2010boiling protectants\u2014alcohols, amines, carboxylic acids, and polyethylene glycols (PEGs)\u2014were systematically evaluated for their ability to increase detector response for polycyclic aromatic hydrocarbons (PAHs), chlorophenols, and nitrophenols. The influence of protectant type, sample solvent, injector temperature, and initial column temperature on signal enhancement was investigated. Among all protectants, PEGs yielded the highest improvements, with average signal increases of 280% for PAHs and 380% for chlorophenols and nitrophenols. The transient nature of the effect was confirmed through alternating injections, ensuring no cumulative influence on subsequent analyses. Application of the QuEChERS method to water and soil samples showed comparable enhancements, with minimal interference from matrix components. Method validation for PEG\u2010400 confirmed excellent linearity (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    &gt; 0.998), two\u2010 to threefold lower LODs, and high precision (RSD &lt; 4.3%), demonstrating robustness and reproducibility. Leveraging a controlled transient matrix effect, this approach achieves several\u2010fold improvement in detection limits without altering chromatographic hardware, providing a simple and adaptable tool for trace\u2010level environmental monitoring.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70285","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:18:57Z","timestamp":1759205937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Enhancement of GC\u2013MS Signal for Environmental Pollutants via the Transient Matrix Effect"],"prefix":"10.1002","volume":"48","author":[{"given":"Michal P.","family":"Dybowski","sequence":"first","affiliation":[{"name":"Faculty of Chemistry Department of Chromatography Institute of Chemical Sciences Maria Curie\u2010Sklodowska University in Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/su15054241"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14982-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202000720"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202400296"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100464"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116611"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.70196"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202400113"},{"key":"e_1_2_8_10_1","article-title":"Miniaturized Ternary Deep Eutectic Solvent\u2010Based Matrix Solid\u2010Phase Dispersion: A Green Sample Preparation Method for the Determination of Chlorophenols in River Sediment","volume":"45","author":"Kamal El\u2010Deen A.","year":"2022","journal-title":"Journal of Separation Science"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.202400173"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.201800098"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200800495"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/20014091076668"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1061934820080158"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900358"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods10102473"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.4c02718"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sscp.202300243"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.11.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.01.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12061226"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116068"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-0305(03)00574-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.114800"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","unstructured":"M. P.DybowskiandK.Siwek \u201cApplication of the Transient Matrix Effect for Determination of Anabolic\u2013Androgenic Steroids in Biological Samples by GC\u2013MS\/MS \u201dForensic Toxicology ahead of print June 26 2025 https:\/\/doi.org\/10.1007\/s11419\u2010025\u201000731\u20106.","DOI":"10.1007\/s11419-025-00731-6"},{"key":"e_1_2_8_27_1","article-title":"QuEChERS\u2010Based Extraction of Emerging Contaminants in Food Samples","volume":"440","author":"Soko\u0142owski A.","year":"2024","journal-title":"Food Chemistry"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300571"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01040-8"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-anchem-071224-093709"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.114265"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2GC03807B"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50531998000300005"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.energyfuels.2c00769"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.03.058"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.05.057"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.07.015"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00822-6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.56530\/lcgc.na.tc2970o5"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25133047"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70285","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T07:23:17Z","timestamp":1764746597000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jssc.70285"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70285","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70285"}}