{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:20:07Z","timestamp":1775496007478,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Traditional approaches, such as gas chromatography\u2010mass spectrometry (GC\u2010MS), are complemented by adopting new liquid chromatographic methods to separate isomeric drug mixtures that are unresolvable by the former technique. This study investigates a series of liquid chromatographic approaches using both traditional and silica hydride stationary phases. These methods focus on the separation of 11 synthetic cannabinoid constitutional isomers. Seven different columns were used to assess the utility of single and serially coupled column approaches under reversed\u2010phase conditions. The best separation using a single column was the use of a Cogent Pentafluorophenyl (RP PFP) stationary phase, where 9 out of 11 constitutional isomers were separated. Concerning using different single columns with the same organic modifier or different organic modifiers with the same column, all compounds of interest were separated using a combination of RP PFP and RP C18 columns using methanol as the organic modifier. Cogent RP C18 separated all constitutional isomers (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>s<\/jats:sub>\n                    \u00a0=\u00a01) in two separate runs, using methanol and acetonitrile individually. The serial coupling of columns, which did not offer better separation compared to the previous techniques, demonstrated either enhanced or diminished selectivity based on column coupling.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70286","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:18:06Z","timestamp":1759205886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Single or Serially Coupled Columns and the Effect of Organic Modifier for the Separation of Constitutional Isomers of the Synthetic Cannabinoid JWH 018"],"prefix":"10.1002","volume":"48","author":[{"given":"Jerimiah J.","family":"Seba","sequence":"first","affiliation":[{"name":"Department of Forensic Sciences The George Washington University  Washington, DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter F.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Department of Forensic Sciences The George Washington University  Washington, DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira S.","family":"Lurie","sequence":"additional","affiliation":[{"name":"Department of Forensic Sciences The George Washington University  Washington, DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cSingle Convention on Narcotic Drugs 1961 \u201d United Nations Treaty Series vol.520 p.151."},{"key":"e_1_2_9_3_1","unstructured":"\u201cConvention on Psychotropic Substances 1971 \u201d United Nations Treaty Series vol.1019 p.175."},{"key":"e_1_2_9_4_1","first-page":"351","volume-title":"Neuropharmacology of New Psychoactive Substances (NPS): The Science Behind the Headlines","author":"Schifano F.","year":"2017"},{"key":"e_1_2_9_5_1","unstructured":"Controlled Substance Analogue Enforcement Act of 1986. Pub. L. No. 99\u2013570 100 Stat. 3207\u201313 (1986). Cites 21 U.S.C. \u00a7\u00a7 802(32)(A) and 813."},{"key":"e_1_2_9_6_1","unstructured":"United States. Synthetic Drug Abuse Prevention Act of 2012 Pub. L. 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