{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:16:18Z","timestamp":1773562578855,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A simple, accurate, cost\u2010effective, and sensitive analysis method for the determination of vancomycin in plasma samples has been reported using high\u2010performance liquid chromatography\u2010tandem mass spectrometry. UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    metal\u2013organic framework was synthesized through a hydrothermal method, 5\u00a0mg of this compound was introduced into 5\u00a0mL of model solution or pretreated plasma adjusted to a pH of 8. The mixture was vortexed for 1\u00a0min and then the sorbent particles were separated by centrifugation. The upper phase of sorbents was removed and the analytes adsorbed were eluted by a 250\u00a0\u00b5L mixture of deionized water (pH 2) and methanol at a 1:1 ratio, v\/v, under vortexing for 4\u00a0min from the sorbent surface. After centrifugation, the eluent was analyzed by the determination system. The synthesized nanoparticles underwent characterization using X\u2010ray diffraction, Fourier transform infrared spectrometry, and scanning electron microscopy. To achieve optimal efficacy, optimization was carried out at every stage of the project, encompassing adsorption, extraction, and desorption processes. Approved validation data consisting of method detection limit (22 and 225\u00a0ng\/mL in deionized water and plasma, respectively) and limit of quantification (73 and 774\u00a0ng\/mL in deionized water and plasma, respectively), a wide linear range of the calibration curve (73\u2013250\u00a0ng\/mL and 774\u20131250\u00a0ng\/mL in deionized water and plasma, respectively), and low relative standard deviations for interday and intraday precisions (\u2264\u00a04.8%) were obtained by the method. The proposed method can be successfully applied in the analysis for the determination of vancomycin in plasma and deionized water samples.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70303","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T06:22:36Z","timestamp":1762582956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Facile Dispersive Solid Phase Extraction of Vancomycin From Plasma and Deionized Water Samples Using UiO\u201066\u2010NH\n                    <sub>2<\/sub>\n                    Metal\u2013Organic Framework Prior to HPLC\u2010MS\/MS Determination"],"prefix":"10.1002","volume":"48","author":[{"given":"Pouria","family":"Sarihi","sequence":"first","affiliation":[{"name":"Food and Drug Safety Research Center, Pharmaceutical Sciences Institute Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Pharmaceutical Analysis Research Center, 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 Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Akbar","family":"Fathi","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Faculty of Chemistry University of Tabriz  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboob","family":"Nemati","sequence":"additional","affiliation":[{"name":"Food and Drug Safety Research Center, Pharmaceutical Sciences Institute Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Gharekhani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analysis Research Center, Pharmaceutical Sciences Institute Tabriz University of Medical Sciences Tabriz 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