{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:18:10Z","timestamp":1789409890613,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22364022"],"award-info":[{"award-number":["22364022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21964021"],"award-info":[{"award-number":["21964021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22064020"],"award-info":[{"award-number":["22064020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chiral covalent organic frameworks (CCOFs) show great potential for chromatographic separation, due to their abundant chiral recognition sites and unique structures. A novel CCOF core\u2010shell composite, CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    , was constructed by post\u2010synthesis modification (PSM) and in\u2010situ growth strategies, and the effect of the amount of acetic acid catalyst on the synthesis of CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    core\u2010shell microspheres was discussed. The prepared CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    microspheres composite was used as a multifunctional chiral stationary phase (CSP) for HPLC enantiomeric separation under normal\u2010phase (NP) and reversed\u2010phase (RP) modes. The experimental results showed that the CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    column exhibited excellent separation performance, with 20 chiral compounds being separated in NP mode and 12 chiral compounds in RP mode, including alcohols, esters, ketones, and amines. Compared with the commercially available Chiralpak AD\u2010H column, the CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    column exhibited good complementarity in enantiomeric separation performance. In addition, the effects of analyte mass, column temperature, and mobile phase composition on the separation were investigated. Good repeatability and stability of the CCOF\u2010301@SiO\n                    <jats:sub>2<\/jats:sub>\n                    column for enantioseparation were observed. This study demonstrates that the CCOFs@SiO\n                    <jats:sub>2<\/jats:sub>\n                    constructed by PSM and in\u2010situ growth strategies have great potential as an HPLC stationary phase.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70322","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T15:40:26Z","timestamp":1763566826000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chiral Covalent Organic Framework Composite CCOF\u2010301@SiO\n                    <sub>2<\/sub>\n                    for Multi\u2010Mode HPLC Enantiomeric Separation"],"prefix":"10.1002","volume":"48","author":[{"given":"Yun\u2010Jie","family":"Li","sequence":"first","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Qiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Jian","family":"Xiong","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Xiu","family":"He","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang\u2010Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Ming","family":"Xie","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ming","family":"Yuan","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation College of Chemistry and Chemical Engineering Yunnan Normal University  Kunming People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010022\u201000181\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.4c00774"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00550"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf032"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS00106D"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00538D"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110330"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216163"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893\u2010022\u201000870\u20103"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.06.089"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110649"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c05973"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216400"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215427"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215249"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00620C"},{"key":"e_1_2_9_18_1","first-page":"11450","article-title":"Observation of Chiral Channels in Helical Covalent Organic Frameworks","volume":"146","author":"Zhang Y. J.","year":"2024","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TA06804F"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c00285"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413675"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00009D"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijch.201800066"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.70101"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810571"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.111146"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202300376"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406256"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117756"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900911"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/b718436k"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac981134m"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.122739"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420269"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.3c05227"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010021\u201003574\u20103"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC02028F"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b12110"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00827F"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.201700223"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2021.122754"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.465014"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202400140"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604\u2010024\u201006524\u20109"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604\u2010021\u201004954\u20103"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604\u2010023\u201005806\u2010y"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.340662"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:43:13Z","timestamp":1765258993000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jssc.70322"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70322","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70322"}}