{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:19:56Z","timestamp":1783012796564,"version":"3.54.6"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Intensive farming practices have necessitated the extensive use of veterinary drugs, raising significant concerns regarding residue contamination. Consequently, long\u2010term monitoring of residues and the evaluation of dietary exposure risks are essential. In this study, 326 pork samples were collected from local supermarkets between October 2024 and April 2025. Methods were developed for the analysis of 25 veterinary drugs (including sulfonamides, tetracyclines, fluoroquinolones, \u03b2\u2010agonists, amphenicols, macrolides, and roxarsone) using high\u2010performance liquid chromatography\u2010tandem mass spectrometry. Roxarsone was extracted using a methanol\/water solution (6:4, v\/v), and amphenicols were extracted with a 2% ammonia in ethyl acetate solution. Other analytes were extracted with acetonitrile containing 2% acetic acid, followed by cleanup via dispersive solid\u2010phase extraction. Chromatographic separation and detection were performed under multiple reaction monitoring conditions in both positive and negative ionization modes. The method exhibited good linearity (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0&gt;\u00a00.99) for all target analytes. Recoveries ranged from 70% to 110% with relative standard deviations below 13%, and limits of quantitation ranged from 0.02 to 5.0\u00a0\u00b5g\/kg. Tetracyclines were the most frequently detected class (detection rate of 63.6%), whereas prohibited substances (\u03b2\u2010agonists and roxarsone) were not detected. Residue levels exhibited seasonal fluctuations, with tetracyclines peaking in October and fluoroquinolones and amphenicols in November. Hazard quotient values for dietary intake were consistently below 1, indicating a low health risk to consumers. The dynamic monitoring of drug residue levels offers a more comprehensive approach compared to static methods, which provides valuable insights to guide the rational use of veterinary drugs.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70422","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:05:41Z","timestamp":1776791141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Residual Status of 25 Veterinary Drugs and Dietary Exposure Assessment of Commercially Available Pork in Guiyang"],"prefix":"10.1002","volume":"49","author":[{"given":"Dandan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science Guizhou University  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science Guizhou University  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Veterinary Medicine College of Veterinary Medicine Southwest University  Rongchang Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongchao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Research and Development Center Guizhou Fuzhiyuan Technology (Group) Co., Ltd.  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Research and Development Center Guizhou Fuzhiyuan Technology (Group) Co., Ltd.  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science Guizhou University  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science Guizhou University  Guiyang Guizhou Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyuan","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine College of Animal Science Guizhou University  Guiyang Guizhou Province 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No.250: List of Prohibited Veterinary Drugs and Other Compounds for Food\u2010Producing Animals \u201dMinistry of Agriculture and Rural Affairs of the People's Republic of China accessed May 30 2025 http:\/\/www.moa.gov.cn\/govpublic\/xmsyj\/202001\/t20200106_6334375.htm."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1454.049"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20\u20100436"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2017.12.015"},{"key":"e_1_2_9_44_1","unstructured":"\u201cAnnouncement No.2292: Withdrawal of Four Fluoroquinolones for Use in Food\u2010Producing Animals \u201dMinistry Of Agriculture And Rural Affairs of the People's Republic of China accessed May 30 2025 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