{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:18:47Z","timestamp":1783459127285,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Resorcinol is widely used as an oxidative dye intermediate in commercial hair coloring products, yet its accurate quantification remains challenging due to its limited native fluorescence and the strong interferences associated with complex cosmetic matrices. In this study, we report a sensitive and selective high\u2010performance liquid chromatography\u2013fluorescence method based on dopamine derivatization for the trace\u2010level determination of resorcinol in hair dye formulations. The analyte was isolated from the sample matrix using ultrasound\u2010assisted extraction with methanol. Under mild alkaline conditions, dopamine rapidly forms a highly fluorescent adduct with resorcinol, substantially enhancing analytical sensitivity and selectivity. The method was optimized with respect to derivatization parameters, chromatographic separation, and detector response. Validation demonstrated excellent linearity over the range of 1\u201375\u00a0ng\/mL (\n                    <jats:italic>r<\/jats:italic>\n                    &gt; 0.999), a low limit of detection (= 0.3\u00a0ng\/mL), and satisfactory recoveries (76.0%\u2013118.0%) across spiked matrices. The robustness of the derivatization procedure was evaluated using Monte\u2010Carlo simulation experiments. Method greenness was assessed using the multicolor tool, yielding a score of 69.9%. Application to commercial products revealed resorcinol concentrations consistent with reported regulatory limits. The proposed method demonstrates promising potential for routine analytical applications; however, further validation, including inter\u2010laboratory studies and comparison with established reference methods, is required to support its suitability for regulatory use.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70441","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:45:52Z","timestamp":1778478352000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Assisted Extraction Coupled With Derivatization for Sensitive High\u2010Performance Liquid Chromatography Determination of Resorcinol in Permanent Hair Dyes"],"prefix":"10.1002","volume":"49","author":[{"given":"Marianna","family":"Ntorkou","sequence":"first","affiliation":[{"name":"Department of Pharmacy Laboratory of Pharmaceutical Analysis Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Letsika","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Laboratory of Pharmaceutical Analysis Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevas D.","family":"Tzanavaras","sequence":"additional","affiliation":[{"name":"Department of Chemistry Laboratory of Analytical Chemistry Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos K.","family":"Zacharis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Laboratory of Pharmaceutical Analysis Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003032694"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203912225"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032710802352605"},{"key":"e_1_2_9_5_1","unstructured":"elstant Opinion of the Scientific Committee on Consumer Safety on Resorcinol (n.d.)."},{"key":"e_1_2_9_6_1","unstructured":"Regulation \u2010 1223\/2009 \u2010 EN\u2014Cosmetic Products Regulation\u2014EUR\u2010Lex (n.d.) https:\/\/eur\u2010lex.europa.eu\/eli\/reg\/2009\/1223\/oj\/eng(Accessed November 28 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