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However, the residues of emamectin benzoate (EMB), spinetoram, and prime metabolites of spinetoram in eggplant remained unclear. In this study, field trials were performed in accordance with good agricultural practice across eight provinces of China. The pesticide formulation was sprayed once at 13.5\u00a0g a.i.\/ha, and the recommended pre\u2010harvest interval was 7 days. For the simultaneous determination of EMB, spinetoram, and its metabolites in eggplant, a modified quick, easy, cheap, effective, rugged, and safe method combined with high\u2010performance liquid chromatography tandem mass spectrometry was developed and validated. The combination of 25\u00a0mg of primary\u2010secondary amine, 25\u00a0mg of Nano\u2010ZrO\n                    <jats:sub>2<\/jats:sub>\n                    , and 5\u00a0mg of multi\u2010walled carbon nanotubes was applied to purify the eggplant extracts. Method validation demonstrated excellent linearity (\n                    <jats:italic>r<\/jats:italic>\n                    \u2265 0.9991), acceptable accuracy with recoveries of 82.7%\u2013102.6%, precision (relative standard deviations \u22647.7%), sensitivity (limits of detection, 6.59 \u00d7 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    \u20133.06 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    \u00a0ng; limits of quantification, 0.0025\u20130.01\u00a0mg\/kg), and matrix effects (\u226425.2%). When harvested after the recommended 7\u2010day interval, the residues of EMB (&lt;0.01\u00a0mg\/kg) and spinetoram (\u22640.025\u00a0mg\/kg) in eggplant were lower than the maximum residue limits in China. The residues of metabolites\n                    <jats:italic>N\u2010<\/jats:italic>\n                    formyl\u2010XDE\u2010175\u2010J and\n                    <jats:italic>N\u2010<\/jats:italic>\n                    demethyl\u2010XDE\u2010175\u2010J in eggplant were lower than the limits of quantification (0.01\u00a0mg\/kg). This study offers recommendations for the effective use of this pesticide formulation on eggplant.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70448","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:31:09Z","timestamp":1779193869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Modified QuEChERS Combined With HPLC\u2010MS\/MS for the Determination of Emamectin Benzoate, Spinetoram, and Their Major Metabolites in Eggplant Field Samples"],"prefix":"10.1002","volume":"49","author":[{"given":"Tao","family":"Pei","sequence":"first","affiliation":[{"name":"School of Chemistry and Biological Engineering University of Science and Technology Beijing  Beijing P. R. 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