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NaDES emerge as versatile, tunable, and biocompatible media that enhance the recovery and stability of diverse phytochemicals through extensive hydrogen\u2011bond networks and customizable polarity. The review summarizes current knowledge on NaDES formation principles, key physicochemical properties, and classification and evaluates their performance across conventional and advanced extraction techniques, including ultrasound, microwave, and pressure\u2011assisted processes. Evidence shows that NaDES frequently outperform traditional organic solvents in selectivity, extraction efficiency, and compound preservation. Their integration into purification workflows, chromatographic and spectroscopic analysis, and sensor platforms highlights growing analytical relevance. Sector\u2011specific applications in food, cosmetics, and pharmaceuticals illustrate the potential for direct formulation, improved bioactivity, and enhanced functional properties. 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