{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:29:03Z","timestamp":1786616943180,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2022J199"],"award-info":[{"award-number":["2022J199"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["202003N4168"],"award-info":[{"award-number":["202003N4168"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Quantifying hydrophilic B vitamins (B1 [(thiamine], B2 [riboflavin], and B3 [nicotinic acid]) in complex functional food matrices presents a significant challenge. Conventional sorbents, such as C18, often exhibit poor retention and low recoveries (50%\u201360%) due to weak hydrophilic interactions. To efficiently extract these target analytes from functional foods, a new sorbent with tailored hydrophilic affinity has been developed by incorporating Co\u2010cyromazine complexes onto halloysite nanotubes. This composite was employed as the sorbent for a spin\u2010tip solid\u2010phase extraction method, which was coupled with liquid chromatography\u2010tandem mass spectrometry analysis. Following comprehensive optimization and validation, the method demonstrates simplicity, accuracy, sensitivity, and cost\u2010effectiveness. It requires only 10\u00a0mg (or 10\u00a0\u00b5L) of functional food sample, while delivering high recoveries (81.3%\u2013107.8%) with good precision (relative standard deviations \u226410.7%). The limits of detection ranged from 0.4 to 2.5\u00a0ng\/mL in liquid matrices and from 0.7 to 8.7\u00a0ng\/g in solid matrices. Practical applicability was confirmed through the successful quantification of vitamins B1, B2, and B3 in various commercial functional foods. Consequently, the developed method provides a reliable and promising analytical tool for the determination of B vitamins, with the potential for extension to other hydrophilic analytes in biological and food matrices.<\/jats:p>","DOI":"10.1002\/jssc.70489","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:34:22Z","timestamp":1783686862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incorporation of Co\u2010Cyromazine Complexes Onto Halloysite Nanotubes as a Spin\u2010Tip Solid\u2010Phase Extraction Sorbent for Determining Hydrophilic B Vitamins in Functional Foods"],"prefix":"10.1002","volume":"49","author":[{"given":"Jiaheng","family":"Yan","sequence":"first","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Chen","sequence":"additional","affiliation":[{"name":"Ningbo Customs Technology Center  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"Bai","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"He","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meikang","family":"Lei","sequence":"additional","affiliation":[{"name":"Hangzhou Customs Technical Center  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Qiao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Key Laboratory of Medicinal Chemistry and Molecular Diagnosis Ministry of Education Hebei University  Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials and Chemical Engineering Ningbo University of Technology  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2018.12.062"},{"key":"e_1_2_10_3_1","first-page":"28","article-title":"B\u2010Complex Vitamin Deficiency and Supplementation","volume":"82","author":"Schellack G.","year":"2016","journal-title":"SA Pharmaceutical Journal"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2025.117124"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201201176"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.70255"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.01.045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.464978"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.128173"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3583"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.7040"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2023.2192282"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.463881"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2024.115989"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.35105"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.1c08054"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2ay01228f"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3dt00389b"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.04.006"},{"key":"e_1_2_10_20_1","first-page":"275","article-title":"Application of Halloysite Nanotubes","volume":"24","author":"Ma Z.","year":"2012","journal-title":"Progress in Chemistry"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0dt03345f"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067319.2022.2047184"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2023.137704"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201801128"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.6b06015"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.110950"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10450\u2010019\u201000186\u20103"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201096812\u2010y"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.04.014"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337\u2010010\u20101564\u20103"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11091526"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.06.022"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157223"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2026.466802"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.134062"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.70489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:40:53Z","timestamp":1786614053000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/jssc.70489"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70489","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70489"}}