{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:19:18Z","timestamp":1787807958950,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","award":["LGC21B050003"],"award-info":[{"award-number":["LGC21B050003"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dextromethorphan is a widely used clinical antitussive, while its enantiomer, levomethorphan, is a controlled substance. Chiral separation and trace detection of the two enantiomers in biological samples are critically important. Herein, a micro\u2010solid\u2010phase extraction method coupled with enantioselective ultra\u2010high performance liquid chromatography\u2013mass spectrometry (UHPLC\u2013MS) was proposed for the analysis of methorphan enantiomers. MOF\u2010199\/cellulose aerogel spheres fabricated via a facile in situ growth strategy were employed as the sorbent. By immersing Cu\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010rich cellulose aerogel in H\n                    <jats:sub>3<\/jats:sub>\n                    BTC (1,3,5\u2010benzene tricarboxylate) solutions at varied concentrations, MOF\u2010199\/cellulose aerogels with tunable MOF\u2010199 loadings (28.8%, 38.1%, 43.8%) were fabricated. Characterization results verified that MOF\u2010199 was uniformly anchored in the pore channels of cellulose aerogel, which not only enhanced its specific surface area from 33.9 to 143.6 m\n                    <jats:sup>2<\/jats:sup>\n                    \/g, but also mitigated the aggregation and poor recyclability of powdered MOF\u2010199. The electrostatic attraction, chelation, and hydrogen\u2010bonding interactions accounted for the effective extraction for dextro\u2010 and levo\u2010methorphan. Under optimized conditions, this method exhibited favorable linearity in the range of 0.02\u201310.0 \u00b5g\/L, with intra\u2010 and inter\u2010day precisions of 4.9%\u20135.0% and 7.7%\u20139.7%, respectively. The limits of detection were 0.01\u20130.02 \u00b5g\/L, respectively. Recoveries of dextro\u2010 and levo\u2010methorphan from urine and hair samples were in the ranges of 88.9%\u2013119.3% and 78.6%\u2013115.7%, respectively. This method provides an effective strategy for the determination of methorphan enantiomers in biological samples, featuring rapid pretreatment, low organic solvent consumption, as well as facile operation.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70506","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:52:41Z","timestamp":1787043161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aerogel Pore\u2010Confined High\u2010Loading MOF\u2010199 for Micro\u2010Solid\u2010Phase Extraction of Methorphan Enantiomer in Biological Samples"],"prefix":"10.1002","volume":"49","author":[{"given":"Shaojing","family":"Huang","sequence":"first","affiliation":[{"name":"College of Materials &amp; Environmental Engineering Hangzhou Dianzi University  Hangzhou 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