{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:56:10Z","timestamp":1790592970055,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Wild\u2010simulated ginseng (linxiashen, LXS) powder, farm\u2010grown ginseng (yuanshen, YS) powder, and farm\u2010grown ginseng decoction pieces (YSDP), as well as the Baoyuan decoction prepared from them (BYD\u2010LXS, BYD\u2010YS, and BYD\u2010YSDP) by boiling, exhibit certain metabolic differences in their chemical composition. To elucidate the holistic molecular profile and differences, a reversed\u2010phase UHPLC\u2010Q\u2010TOF\u2010MS\n                    <jats:sup>E<\/jats:sup>\n                    metabolomics strategy with an ACQUITY HSS T3 stationary phase was applied to characterize and discover differential chemical markers. In total, 293, 663, 311, and 645 compounds (including 22, 13, 24, and 28 rare ginsenosides) were annotated in LXS\/YS, BYD\u2010LXS\/BYD\u2010YS, YS\/YSDP, and BYD\u2010YS\/BYD\u2010YSDP respectively. Based on PCA and OPLS\u2010DA, 87, 222, 95, and 168 chemical markers (including 8, 7, 13, and 3 rare ginsenosides) were annotated in LXS\/YS, BYD\u2010LXS\/BYD\u2010YS, YS\/YSDP, and BYD\u2010YS\/BYD\u2010YSDP decoctions, respectively. Secondary metabolites such as triterpene saponins were found to be present at higher levels in LXS decoction and BYD\u2010LXS decoction. The amount of components eluted from YSDP decoction was significantly higher than that from the decoction of YS powder. In addition, Support Vector Machine and Back Propagation Neural Network models with feature selection nested within cross\u2010validation were constructed to classify LXS\/YS, BYD\u2010LXS\/BYD\u2010YS, YS\/YSDP, and BYD\u2010YS\/BYD\u2010YSDP decoctions, achieving 100%, 100%, 100%, and 94.44% classification accuracies, respectively. This study provides a basis for the quality assessment of ginseng and Baoyuan decoction, as well as for the development and utilization of rare ginsenosides.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70516","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:01:37Z","timestamp":1789480897000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Wild\u2010Simulated Ginseng Powder, Cultivated Ginseng Powder, Cultivated Ginseng Decoction Pieces, and Baoyuan Decoction Containing Wild\u2010Simulated Ginseng and Cultivated Ginseng by UHPLC\u2010Q\u2010TOF\u2010MS\/MS and Non\u2010Targeted Metabolite Profiling"],"prefix":"10.1002","volume":"49","author":[{"given":"Han","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Chinese Materia Medica, State Key Laboratory for Quality Insurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"},{"name":"Graduate School of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yute","family":"Zhong","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, State Key Laboratory for Quality Insurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, State Key Laboratory for Quality Insurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, State Key Laboratory for Quality Insurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"},{"name":"Postdoctoral Research Station China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, State Key Laboratory for Quality Insurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Cui","sequence":"additional","affiliation":[{"name":"Liaoning Good Nurse Pharmaceutical (Group) Co. 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