{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:55:18Z","timestamp":1790823318631,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1600302"],"award-info":[{"award-number":["2023YFD1600302"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172309"],"award-info":[{"award-number":["32172309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A magnetic molecularly imprinted polymer (MMIP) with high specificity for pyrethroid pesticides was successfully synthesized via a surface molecular imprinting strategy. Using fenvalerate as the template, density functional theory (DFT) calculations were performed to systematically evaluate four candidate functional monomers: methacrylic acid (MAA), acrylic acid (AA), 4\u2010vinylpyridine (4\u2010VP), and allyl\u2010\u03b2\u2010cyclodextrin (allyl\u2010\u03b2\u2010CD). Computational analyses revealed that allyl\u2010\u03b2\u2010CD yields a significantly increased imprinting factor, underscoring its superior capacity to confer adsorption selectivity. Binding energy calculations further elucidated the molecular recognition mechanism underlying the MMIP\u2013template interaction. Comprehensive physicochemical characterization, including X\u2010ray diffraction (XRD), scanning\/transmission electron microscopy (SEM\/TEM), and Fourier transform infrared spectroscopy (FT\u2010IR), confirmed both the structural integrity and surface morphology of the resulting polymer. To demonstrate practical utility, MMIPs were employed in magnetic dispersive solid\u2010phase extraction (MDSPE) for the simultaneous purification and enrichment of six pyrethroid pesticides (Pyrs) from apple and cabbage matrices. By coupling MDSPE with high\u2010performance liquid chromatography\u2012tandem mass spectrometry (HPLC\u2012MS\/MS), a robust analytical protocol was developed and validated for the determination of pyrethroid residues in fruits and vegetables. Recovery experiments across multiple fortification levels yielded mean recoveries of 72%\u2013109%, with relative standard deviations (RSDs) of 0.65%\u20135.04%. This validated MDSPE\u2013HPLC\u2013MS\/MS method provides a cost\u2010effective and time\u2010saving reliable analytical tool for routine monitoring of pyrethroid residues in fresh produce, contributing to improved food safety surveillance and regulatory compliance, and offering practical applicability for routine food safety monitoring laboratories.<\/jats:p>","DOI":"10.1002\/jssc.70530","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:56:16Z","timestamp":1790819776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Computationally Guided Design of Magnetic Molecularly Imprinted Polymers for the Selective Determination of Pyrethroid Pesticides in Foods"],"prefix":"10.1002","volume":"49","author":[{"given":"Yiliu","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"},{"name":"Key Laboratory of Geriatric Nutrition and Health Beijing Technology and Business University Ministry of Education  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanxia","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Bioengineering Beijing Polytechnic University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"She","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality and Safety of Agro\u2010Products\/Institute of Quality Standardization &amp; Testing Technology for Agro\u2010Products Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Abd El\u2010Aty","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Veterinary Medicine Cairo University  Giza Egypt"},{"name":"Department of Medical Pharmacology Medical Faculty Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.112070"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26133811"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311\u2010018\u20100765\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.113951"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2018.12.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins15060401"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3390\/foods10010189","article-title":"Determination of Three Typical Metabolites of Pyrethroid Pesticides in Tea Using a Modified QuEChERS Sample Preparation by Ultra\u2010High Performance Liquid Chromatography Tandem Mass Spectrometry","volume":"10","author":"Chen H.","year":"2021","journal-title":"Foods"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.06.011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202100581"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2018.07.070"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13172841"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10965\u2010022\u201003036\u2010z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/bios12060402","article-title":"Recent Advances in the Recognition Elements of Sensors to Detect Pyrethroids in Food: A Review","volume":"12","author":"Zhang L.","year":"2022","journal-title":"Biosensors"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"5758","DOI":"10.3390\/ijms23105758","article-title":"Study on the Preparation of Estrone Molecularly Imprinted Polymers and Their Application in a Quartz Crystal Microbalance Sensor via a Computer\u2010Assisted Design","volume":"23","author":"Liu J.","year":"2022","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.70530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:56:17Z","timestamp":1790819777000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jssc.70530"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70530","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70530"}}