{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:56:07Z","timestamp":1790592967837,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cationic cellulose paper is a promising adsorbent for acidic compounds in water. However, cellulose modified with glycidyl trimethyl ammonium chloride (EPTAC) often exhibits compromised structural integrity and readily disperses in water. In this study, a Gemini quaternary ammonium salt (Gemini\u2010QAS) was synthesized via nucleophilic substitution of\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    ',\n                    <jats:italic>N<\/jats:italic>\n                    '\u2010tetramethyl\u20101,6\u2010hexanediamine with epichlorohydrin and subsequently used for the etherification of cellulose paper. Fourier transform infrared spectroscopy, X\u2010ray photoelectron spectroscopy, and zeta potential analyses confirmed the successful incorporation of the Gemini\u2010QAS onto the cellulose substrate. Tensile testing demonstrated that the Gemini\u2010modified cellulose paper (GCP) exhibited enhanced mechanical strength in both dry (25.16\u00a0MPa) and wet (1.54 KN\/m) states, and the wet tensile strength ratio was 0.29, whereas EPTAC\u2010modified cellulose paper showed decreased wet tensile strength (0.51 KN\/m) and ratio (0.16). Batch experiments demonstrated that the optimal adsorption and desorption conditions for GCP on 12 weakly acidic non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) were pH 7.0, an adsorption time of 30\u00a0min, and an eluent of 2% formic acid\u2010methanol. Then, these 12 NSAIDs were extracted by GCP from real water samples and quantified by high\u2010performance liquid chromatography\u2010tandem mass spectrometry. The analytical method achieved limits of detection ranging from 0.02 to 0.64 \u00b5g\/L and limits of quantification between 0.07 and 2.11 \u00b5g\/L. Precision, expressed as intra\u2010day relative standard deviation (RSD), remained below 10%, and inter\u2010day RSD below 12%. The relative recoveries ranged from 71% to 102% at spiking levels of 10 and 50 \u00b5g\/L, while recoveries at 1 \u00b5g\/L ranged from 65.1% to 89.7% due to more pronounced matrix effects. This work successfully resolves the poor aqueous stability and fiber dispersion issues of EPTAC\u2010modified cellulose, providing a green, low\u2010cost, and robust paper\u2010based sorptive phase for trace NSAID monitoring in environmental water, which aligns with the principles of sustainable analytical chemistry.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70537","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T03:01:17Z","timestamp":1789354877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of Gemini\u2010Functionalized Cellulose Paper Sorptive Phases for Enrichment of Non\u2010Steroidal Anti\u2010Inflammatory Drugs in Water"],"prefix":"10.1002","volume":"49","author":[{"given":"Shuai","family":"Luo","sequence":"first","affiliation":[{"name":"Guangzhou Institute of Chemistry Chinese Academy of Sciences  Guangzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Testing Technical Services (Guangzhou) Co. Ltd.  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Chemistry Chinese Academy of Sciences  Guangzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou\u2010Yang","family":"Xiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Papermaking and Paper\u2010based Materials South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua\u2010Jie","family":"Lai","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Chemistry Chinese Academy of Sciences  Guangzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"CAS Testing Technical Services (Guangzhou) Co. Ltd.  Guangzhou China"},{"name":"CAS Engineering Laboratory for Special Fine Chemicals Chinese Academy of Sciences  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Institute of Chemistry Chinese Academy of Sciences  Guangzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"CASH GCC Shaoguan Research Institute of Advanced Materials  Nanxiong China"},{"name":"CASH GCC (Nanxiong) Research Institute of Advanced Materials Co., Ltd  Nanxiong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11157\u2010025\u201009735\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11270\u2010023\u201006239\u20102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hazadv.2024.100477"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecohyd.2024.04.007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107638"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106222"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.4c05599"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165317"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117409"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115624"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216\u2010025\u201006179\u20102"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.6b02771"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29020380"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463745"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.112340"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.465158"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2012.07.005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.01.022"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117894"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117659"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.09.052"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0ay00702a"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sampre.2023.100051"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2022.463166"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2024.342841"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.118263"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202200042"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.116397"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.70076"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coco.2024.102112"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6978434"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010021\u201004406\u20104"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2019.01.034"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2021.129879"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/01932691.2023.2210210"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10086\u2010022\u201002022\u20109"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.117495"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2013.08.015"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010024\u201006132\u2010z"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fpsl.2025.101613"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2024.108275"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surfin.2025.108043"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067319.2019.1646737"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2024.465058"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2022.126979"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2019.10.021"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sampre.2025.100148"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.70537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:02:00Z","timestamp":1790589720000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/jssc.70537"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70537","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70537"}}