{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:36Z","timestamp":1791528576180,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Comprehensive analysis of migrating compounds from plastic food contact materials (FCMs) is analytically demanding due to the structural diversity and broad physicochemical properties of intentionally and non\u2010intentionally added substances (IAS and NIAS). This necessitates the development of advanced, multidimensional separation techniques coupled with high\u2010resolution detection for trace\u2010level characterization. Five million tones of chemical additives are incorporated into plastic FCMs annually, which is concerning considering the health risks associated with human exposure to migrating chemicals. This study provides a simplified green sorptive sampling loop for detecting and quantifying IAS and NIAS that migrate from FCMs during everyday use. A polydimethylsiloxane (PDMS) sorptive sampler loop was used as the sampling device, allowing migrated compounds to be enriched directly from the sample matrix. After extraction, the same sampler format was compatible with two analytical workflows: thermal desorption directly into the GC inlet for GC\u00d7GC\u2013TOFMS analysis, or liquid back\u2010extraction into solvent for subsequent UHPLC\u2010IMS\u2010MS analysis. Complementary chromatography and ion mobility high\u2010resolution mass spectrometry (UHPLC\u2013IMS\u2013MS and GC\u00d7GC\u2013TOFMS) enabled the detection and quantification of a range of chemical compounds at trace levels, including phthalates, UV absorbers, stabilizers, surfactants, and hydrocarbons. Over 30 compounds were detected as migrating from FCMs using GC\u2013MS, and 26 compounds were identified using LC\u2013MS. Unknown target identification using LC\u2013MS was aided by the use of collision cross section (CCS) values, thus strengthening putative identification. Limits of detection of the eight target analytes ranged from 0.023 to 97\u00a0ng L\n                    <jats:sup>\u22121<\/jats:sup>\n                    for LC\u2013MS and IAS were detected at concentrations ranging from 0.0065 to \u223c25\u00a0\u00b5g L\n                    <jats:sup>\u2212\u00a01<\/jats:sup>\n                    . Our study exemplifies the wide range of chemical compounds that migrate from FCMs during everyday FCM use. The green sampling technique presented here allowed the quantification of daily exposure to these chemicals and has potential application to human health and environmental risk assessments.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70549","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:59:32Z","timestamp":1791525572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Sorptive Sampling Coupled With UHPLC\u2013IMS\u2013MS and GC\u00d7GC\u2013TOFMS for Characterization of Migrating Substances From Plastic Food Contact Materials"],"prefix":"10.1002","volume":"49","author":[{"given":"Gizelle Roque","family":"van Niekerk","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Naud\u00e9","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelien","family":"Wooding","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2021.2012599"},{"key":"e_1_2_10_3_1","unstructured":"Single\u2010Use Plastics: A Roadmap for Sustainability(UNEP 2018)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi9010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1071\/EN21033"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00724"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2017.10.024"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00736"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c01103"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c02853"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2024.117550"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jasms.0c00375"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592\u2010023\u201002078\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c6ay00492j"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032711003783077"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.11.095"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593330.2012.698653"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2025.466453"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2023.2291695"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.03.057"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021\u20109673(01)80947\u2010X"},{"key":"e_1_2_10_22_1","unstructured":"European Union \u201cCommission Regulation (EU) No 10\/2011 of 14 January 2011 on Plastic Materials and Articles Intended to Come Into Contact With Food \u201dOfficial Journal of the European Union published January 15 2011 https:\/\/eur\u2010lex.europa.eu\/eli\/reg\/2011\/10\/oj\/eng."},{"key":"e_1_2_10_23_1","unstructured":"T.Colborn \u201cTEDX List of Potential Endocrine Disruptors \u201dThe Endocrine Disruptor Exchange (TEDX) accessed November 11 2021 http:\/\/endocrinedisruption.org\/endocrine\u2010disruption\/tedx\u2010list\u2010of\u2010potential\u2010endocrine\u2010disruptors\/chemicalsearch."},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2023.111652"}],"container-title":["Journal of Separation Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jssc.70549","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jssc.70549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:59:33Z","timestamp":1791525573000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jssc.70549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jssc.70549"],"URL":"https:\/\/doi.org\/10.1002\/jssc.70549","archive":["Portico"],"relation":{},"ISSN":["1615-9306","1615-9314"],"issn-type":[{"value":"1615-9306","type":"print"},{"value":"1615-9314","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70549"}}