{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:03Z","timestamp":1791355923007,"version":"4.3.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Separation Science"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The conformationally flexible 2\u2010methylbutyl structural motif represents a small chiral center, which cannot engage in polar interactions with chiral stationary phases (e.g., hydrogen bonds), which often play a key role in enantioselective recognition. In this contribution, racemic liquid crystalline materials sharing the 2\u2010methylbutyl group were analyzed by enantioselective high\u2010performance liquid chromatography, and the studied analyte set also included diastereomeric compounds with additional chiral centers based on the lactate unit. As the non\u2010chiral parts of the analytes are rigid and bulky, this disbalance in size and flexibility further complicates enantioseparation of such materials. The separations were done under either polar organic mode or reversed\u2010phase liquid chromatography conditions to enhance the less polar interactions with the chiral stationary phases. Two polysaccharide chiral stationary phases were employed\u2014coated\n                    <jats:italic>tris<\/jats:italic>\n                    (5\u2010chloro\u20102\u2010methylcarbamate) amylose and immobilized\n                    <jats:italic>tris<\/jats:italic>\n                    (3\u2010chloro\u20105\u2010methylphenylcarbamate) amylose. Baseline enantioseparation of all racemic samples was accomplished in less than 9\u00a0minutes. Effects of analytes\u2019 structural variations on enantioselectivity are discussed, and the differences between results on the two chiral stationary phases are assessed.\n                  <\/jats:p>","DOI":"10.1002\/jssc.70552","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:19:28Z","timestamp":1791353968000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enantioselective HPLC of Liquid Crystals Bearing a Small and Flexible 2\u2010Methylbutyl Chiral Center"],"prefix":"10.1002","volume":"49","author":[{"given":"Ter\u00e9zia","family":"Jurkovi\u010dov\u00e1","sequence":"first","affiliation":[{"name":"Institute of Physics of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cigl","sequence":"additional","affiliation":[{"name":"Institute of Physics of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u011bra","family":"Hamplov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Physics of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edra","family":"Novotn\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Physics of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Va\u0148k\u00e1tov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Physics of the Czech Academy of Sciences  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/9783527671403","volume-title":"Handbook of Liquid Crystals","author":"Goodby J. 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