{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:41:38Z","timestamp":1697780498864},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,2,19]],"date-time":"2004-02-19T00:00:00Z","timestamp":1077148800000},"content-version":"vor","delay-in-days":8449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Supramol. Struct. Cell. Biochem."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The immune responses to several antigens were compared in the <jats:italic>I\u2010A<\/jats:italic> mutant mouse strain B6.C\u2010<jats:italic>H<\/jats:italic>\u20102<jats:sup><jats:italic>bm<\/jats:italic>12<\/jats:sup> and the wild\u2010type strain C57BL\/6. With a lymph node cell proliferation assay, the response to two of these antigens, beef insulin and (TG)A\u2010L, was demonstrated to be controlled by a gene in the <jats:italic>I\u2010A<\/jats:italic><jats:sup>b<\/jats:sup> region. B6.C\u2010<jats:italic>H<\/jats:italic>\u20102<jats:sup><jats:italic>bm<\/jats:italic>12<\/jats:sup> mice failed to respond to beef insulin, while their responses to (TG)A\u2010L, DNP\u2010OVA and PPD were comparable with those of the wild\u2010type strain C57BL\/6. Taken together with previous studies, these data suggest that the product of a single pleiotropic <jats:italic>I\u2010A<\/jats:italic> gene, an la molecule, functions as a histocompatibility, la, and MLR antigen, as well as a necessary component for <jats:italic>Ir<\/jats:italic> gene function. Furthermore, the data reported here demonstrate that la molecules have multiple functional \u201c<jats:italic>Ir<\/jats:italic> determinants,\u201d one of which has been altered in the B6.C\u2010<jats:italic>H<\/jats:italic>\u20102<jats:sup><jats:italic>bm<\/jats:italic>12<\/jats:sup> mutant. The B6.C\u2010<jats:italic>H<\/jats:italic>\u20102<jats:sup><jats:italic>bm<\/jats:italic>12<\/jats:sup> mice, therefore, represent a powerful analytical tool for the understanding of the cellular and molecular basis for <jats:italic>Ir<\/jats:italic> gene control of the immune response.<\/jats:p>","DOI":"10.1002\/jsscb.1981.380160202","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T17:14:14Z","timestamp":1117300454000},"page":"115-120","source":"Crossref","is-referenced-by-count":1,"title":["<i>I<\/i>\u2010<i>A<\/i> Mutation resulted in a selective loss of an antigen\u2010specific <i>Ir<\/i> gene function"],"prefix":"10.1002","volume":"16","author":[{"given":"C. Shirley","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan S.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted H.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4019.273"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60208-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.143.6.1439"},{"key":"e_1_2_1_5_2","first-page":"1507","volume":"5","author":"Meo T","year":"1973","journal-title":"Transplant Proc"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/243043a0"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.138.5.1194"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/B978-0-12-401660-6.50033-3","volume-title":"The Role of Products of the Histocompatibility Gene Complex in Immune Response.","author":"Katz DH","year":"1976"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01563941"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.150.6.1323"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/285340a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01567775"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.117.1.55"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.149.2.436"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.4049\/jimmunol.117.5_Part_1.1594","volume":"117","author":"Lipsky PE","year":"1974","journal-title":"J Immunol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.123.1.471","volume":"123","author":"Rosenwasser LF","year":"1979","journal-title":"J Immunol"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.140.4.977"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.4049\/jimmunol.124.6.2909","volume":"124","author":"Markman M","year":"1980","journal-title":"J Immunol"},{"key":"e_1_2_1_19_2","unstructured":"NairnR YamagaK NathensonSG:Annu Rev Genet 1980."},{"key":"e_1_2_1_20_2","unstructured":"McKeanDJ MelvoldRW DavidC:Immunogenetics 1981(in press)."}],"container-title":["Journal of Supramolecular Structure and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsscb.1981.380160202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsscb.1981.380160202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T11:51:58Z","timestamp":1697716318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jsscb.1981.380160202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jsscb.1981.380160202"],"URL":"https:\/\/doi.org\/10.1002\/jsscb.1981.380160202","archive":["Portico"],"relation":{},"ISSN":["0275-3723","1547-1748"],"issn-type":[{"value":"0275-3723","type":"print"},{"value":"1547-1748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}