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Cells heterozygous for the xeroderma pigmentosum genotype showed normal rates of UV induced unscheduled DNA synthesis under conditions in which the rate of poly(ADP\u2010ribose) synthesis was one\u2010half the rate of normal cells. The addition of theophylline, a potent inhibitor of poly(ADP\u2010ribose) polymerase, to the culture medium of normal cells blocked over 90% of the conversion of NAD to poly(ADP\u2010ribose) following treatment with UV or N\u2010methyl\u2010N\u2032\u2010nitro\u2010N\u2010nitro\u2010soguanidine but did not affect the rate of unscheduled DNA synthesis.<\/jats:p>","DOI":"10.1002\/jsscb.380170110","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T13:16:36Z","timestamp":1117286196000},"page":"87-90","source":"Crossref","is-referenced-by-count":8,"title":["Unscheduled synthesis of DNA and poly(ADP\u2010ribose) in human fibroblasts following DNA damage"],"prefix":"10.1002","volume":"17","author":[{"given":"Lynette Salter","family":"McCurry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myron K.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.46.070177.000523"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0027686"},{"key":"e_1_2_1_4_2","first-page":"1797","volume":"40","author":"Jacobson MK","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(72)90316-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90071-3"},{"key":"e_1_2_1_7_2","first-page":"1501","volume":"28","author":"Schein PS","year":"1968","journal-title":"Cancer Res"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1042\/bj1400487","volume":"140","author":"Gunnarrson R","year":"1974","journal-title":"Biochem J"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(73)80656-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.21.7.789"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/bst0040635","volume":"4","author":"Davies MI","year":"1971","journal-title":"Biochem Soc Trans"},{"key":"e_1_2_1_12_2","first-page":"1226","volume":"29","author":"Schein PS","year":"1969","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_2","first-page":"1803","volume":"40","author":"Rankin PW","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/282740a0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1980.tb04528.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-80-2-221"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553007014551491"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0021-9258(19)70002-7","volume":"256","author":"McCurry LS","year":"1981","journal-title":"J Biol Chem"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.5933"},{"key":"e_1_2_1_20_2","first-page":"362","volume":"33","author":"Cleaver JE","year":"1973","journal-title":"Cancer Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(78)80627-9"},{"key":"e_1_2_1_22_2","first-page":"619","volume":"38","author":"Jacobson EL","year":"1979","journal-title":"Fed Proc"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/283593a0"}],"container-title":["Journal of Supramolecular Structure and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjsscb.380170110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jsscb.380170110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T10:01:19Z","timestamp":1698832879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jsscb.380170110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/jsscb.380170110"],"URL":"https:\/\/doi.org\/10.1002\/jsscb.380170110","archive":["Portico"],"relation":{},"ISSN":["0275-3723","1547-1748"],"issn-type":[{"value":"0275-3723","type":"print"},{"value":"1547-1748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}