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The current study tested the hypotheses that nicotine dependence partially mediates the relations between PTSD and both panic attacks and panic disorder within a nationally representative sample of 5,692 (3,020 women; M<jats:sub><jats:italic>Age<\/jats:italic><\/jats:sub> = 45, SD = 18) adults from the National Comorbidity Survey\u2013Replication. Results were consistent with hypotheses. 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