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We therefore aimed to investigate gray matter volume (GMV) and resting state functional connectivity (RSFC) correlates of UD attachment in adolescents. Based on previous neuroimaging studies of trauma effects, we hypothesized that the structure of the amygdala and hippocampus and the FC of the latter would be linked to UD attachment. Anatomical and RSFC data were collected from a mixed group of adolescents (<jats:italic>N<\/jats:italic> = 74) with symptoms of posttraumatic stress disorder (PTSD) related to childhood sexual abuse (CSA), anxiety\/depressive symptoms, and without psychiatric disorder as part of the Emotional Pathways\u2019 Imaging Study in Clinical Adolescents (EPISCA). Bilateral volumes of the amygdala and hippocampus were measured using the FMRIB Software Library, and RSFC of the hippocampus was assessed using seed\u2010based correlation. UD attachment was measured using the Adult Attachment Interview. Hierarchical regression and correlation were used to assess the associations between UD status (continuous and categorical), brain structure, and FC, adjusting for a general psychopathology factor, puberty stage, gender, age, and IQ. UD attachment was associated with a smaller left hippocampal volume, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = .23, and a higher level of FC between the hippocampus and the middle temporal gyrus and lateral occipital cortex. The associations among UD attachment, specific brain structure, and FC across psychopathological classifications shows promise for dimensional complements to the dominant classificatory approach in clinical research and practice.<\/jats:p>","DOI":"10.1002\/jts.22432","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:19:28Z","timestamp":1564499968000},"page":"742-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Unresolved\u2013Disorganized Attachment is Associated With Smaller Hippocampus and Increased Functional Connectivity Beyond Psychopathology"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-2723","authenticated-orcid":false,"given":"Marie\u2010Jos\u00e9","family":"van Hoof","sequence":"first","affiliation":[{"name":"Curium\u2010LUMC, Department of Child and Adolescent Psychiatry Leiden University Medical Center  Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC)  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5147-7939","authenticated-orcid":false,"given":"Madelon","family":"Riem","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University  Tilburg the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-7825","authenticated-orcid":false,"given":"Amy","family":"Garrett","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nienke","family":"Pannekoek","sequence":"additional","affiliation":[{"name":"SU\/UCT MRC Unit on Risk and Resilience in Mental Disorders Department of Psychiatry Stellenbosch University  Stellenbosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-1633","authenticated-orcid":false,"given":"Nic","family":"van der Wee","sequence":"additional","affiliation":[{"name":"Leiden Institute for Brain and Cognition (LIBC)  Leiden the Netherlands"},{"name":"Department of Psychiatry, Leiden University Medical Center Leiden University  Leiden the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-454X","authenticated-orcid":false,"given":"Marinus","family":"van IJzendoorn","sequence":"additional","affiliation":[{"name":"Faculty of Social and Behavioural Sciences Leiden University  Leiden the Netherlands"},{"name":"Department of Psychology, Education, and Child studies Erasmus University  Rotterdam the Netherlands"},{"name":"Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine University of Cambridge  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8673-2207","authenticated-orcid":false,"given":"Robert","family":"Vermeiren","sequence":"additional","affiliation":[{"name":"Curium\u2010LUMC, Department of Child and Adolescent Psychiatry Leiden University Medical Center  Leiden the Netherlands"},{"name":"Leiden Institute for Brain and Cognition (LIBC)  Leiden the Netherlands"},{"name":"Department of Child and Adolescent Psychiatry VU University Medical Center  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,30]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Manual for the Youth Self\u2010Report and 1991 profile","author":"Achenbach T. 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