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The disproportionate exposure to CV among African American boys heightens their susceptibility to substance use and related problems. Depressive symptoms are linked to both CV exposure and adolescent substance use; however, their role in the link between CV exposure and substance use in African American male adolescents has received little attention. The current study examined whether depressive symptoms mediate or moderate the associations between CV exposure and substance use among African American male adolescents. Participants were 225 African American adolescent boys in Baltimore, Maryland who completed measures of CV exposure and depressive symptoms in 10th grade and measures of substance use in 10th and 11th grades. Hierarchal linear regression analyses indicated that depressive symptoms moderated associations between violent victimization and alcohol and tobacco use, <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = .21\u2013.30, <jats:italic>p<\/jats:italic>s &lt; .001. There was a positive association between CV victimization and alcohol and tobacco use among those who reported high levels of depressive symptoms but not low levels. Depressive symptoms also moderated the link between witnessing CV and alcohol use such that witnessing CV was negatively related to alcohol use among those who reported high levels of depressive symptoms only. The findings suggest that depressive symptoms may play an important role in differentiating alcohol and tobacco use outcomes in CV\u2010exposed African American boys. Prevention efforts should assess for depressive symptoms to identify adolescent boys with the highest risk of substance use.<\/jats:p>","DOI":"10.1002\/jts.22566","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:20:50Z","timestamp":1598581250000},"page":"1039-1047","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Depressive Symptoms in Substance Use Among African American Boys Exposed to Community Violence"],"prefix":"10.1002","volume":"33","author":[{"given":"Rachel M.","family":"Tache","sequence":"first","affiliation":[{"name":"Department of Psychology The George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon F.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Psychology The George Washington University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Ialongo","sequence":"additional","affiliation":[{"name":"Department of Mental Health Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Multiple regression: Testing and interpreting interactions","author":"Aiken L. 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