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The UP has been shown to be effective across many disorders, including generalized anxiety disorder, major depressive episode (MDE), and panic disorder, that commonly codevelop following trauma exposure. The present study represented the first randomized controlled trial of the UP in the treatment of trauma\u2010related psychopathology, including posttraumatic stress disorder (PTSD), depression, and anxiety symptoms. Adults (<jats:italic>N<\/jats:italic> = 43) who developed posttraumatic psychopathology that included PTSD, MDE, or an anxiety disorder after sustaining a severe injury were randomly assigned to receive 10\u201314 weekly, 60\u2010min sessions of UP (<jats:italic>n<\/jats:italic> = 22) or usual care (<jats:italic>n<\/jats:italic> = 21). The primary treatment outcome was PTSD symptom severity, with secondary outcomes of depression and anxiety symptom severity and loss of diagnosis for any trauma\u2010related psychiatric disorder. Assessments were conducted at intake, posttreatment, and 6\u2010month follow\u2010up. Posttreatment, participants who received the UP showed significantly larger reductions in PTSD, Hedges\u2019 <jats:italic>g<\/jats:italic> = 1.27; anxiety, Hedges\u2019 <jats:italic>g<\/jats:italic> = 1.20; and depression symptom severity, Hedges\u2019 <jats:italic>g<\/jats:italic> = 1.40, compared to those receiving usual care. These treatment effects were maintained at 6\u2010month follow\u2010up for PTSD, anxiety, and depressive symptom severity. Statistically significant posttreatment loss of PTSD, MDE, and agoraphobia diagnoses was observed for participants who received the UP but not usual care. This study provides preliminary evidence that the UP may be an effective non\u2013trauma\u2010focused treatment for PTSD and other trauma\u2010related psychopathology.<\/jats:p>","DOI":"10.1002\/jts.22650","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T18:04:55Z","timestamp":1610820295000},"page":"563-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["A Pilot Study of the Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Treating Posttraumatic Psychopathology: A Randomized Controlled Trial"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4349-0022","authenticated-orcid":false,"given":"Meaghan L.","family":"O'Donnell","sequence":"first","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winnie","family":"Lau","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Chisholm","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-1311","authenticated-orcid":false,"given":"James","family":"Agathos","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Little","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-3972","authenticated-orcid":false,"given":"Sonia","family":"Terhaag","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Brand","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Putica","sequence":"additional","affiliation":[{"name":"Phoenix Australia Centre for Posttraumatic Mental Health  Melbourne Australia"},{"name":"Department of Psychiatry University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C. 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