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We examined the links between different forms of childhood trauma (i.e., abuse, neglect, cumulative trauma) and cardiovascular health and explored potential mediators. Cross\u2010sectional data from 1,251 participants in the National Survey of Midlife Development in the United States\u2019 II Biomarker Project were analyzed. Path analyses were conducted to examine the associations between childhood trauma and cardiovascular health (i.e., American Heart Association's Life's Simple 7 [LS7] score). Depressive symptoms and sleep quality were explored as potential mediators, and exploratory analyses examined whether these associations were moderated by sex. Women reported more severe childhood emotional and sexual abuse and emotional neglect, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001 to <jats:italic>p\u00a0<\/jats:italic>=\u00a0.018, and higher LS7 scores, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027, than men. Path analyses demonstrated the total effects of increasing severity of all forms of childhood trauma with LS7 scores were significant, and cumulative childhood trauma was inversely associated with LS7 score <jats:italic>B<\/jats:italic>s\u00a0=\u00a0\u20100.306\u2013 \u20100.076, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001\u2013<jats:italic>p\u00a0<\/jats:italic>=\u00a0.048. The range of total effects of different forms of childhood trauma on LS7 scores mediated by depressive symptoms and sleep quality was 26.8%\u201357.5%. Sex moderated the associations between all forms of childhood trauma and cardiovascular health. Longitudinal studies are needed that examine mediators of the associations between childhood trauma and cardiovascular health. Findings suggest sex\u2010specific, trauma\u2010informed approaches for cardiovascular disease prevention in adults exposed to childhood trauma may be needed.<\/jats:p>","DOI":"10.1002\/jts.22752","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T10:42:09Z","timestamp":1637404929000},"page":"409-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigating the associations between childhood trauma and cardiovascular health in midlife"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-5546","authenticated-orcid":false,"given":"Billy A.","family":"Caceres","sequence":"first","affiliation":[{"name":"Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura E.","family":"Britton","sequence":"additional","affiliation":[{"name":"Columbia University School of Nursing  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamnia I.","family":"Cortes","sequence":"additional","affiliation":[{"name":"School of Nursing The University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour","family":"Makarem","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University Irving Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakira F.","family":"Suglia","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chiabu.2017.08.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000430"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpsp.12191"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.107.2.238"},{"key":"e_1_2_6_6_1","unstructured":"Bernstein D. 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